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Important Disorders and Treatments Associated With Eosinophilia

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Cause or Associated Disorder	Examples
Allergic or atopic disorders	Asthma Allergic bronchopulmonary aspergillosis Allergic rhinitis Atopic dermatitis Episodic angioedema with eosinophilia Medication reactions (eg, to antibiotics or NSAIDs) Milk-protein allergy Occupational lung disease Urticaria
Systemic rheumatic diseases, vasculitic or granulomatous disorders (especially those involving the lungs)	Eosinophilic fasciitis Eosinophilic granulomatosis with polyangiitis Idiopathic eosinophilic synovitis IgG4-related disease Inflammatory bowel disease Kimura disease Polyarteritis nodosa Post myocardial infarction syndrome (Dressler syndrome) Progressive systemic sclerosis (scleroderma) Rheumatoid arthritis Sarcoidosis Sjögren syndrome Systemic lupus erythematosus
Endocrine disorders	Adrenal hypofunction
Immune disorders (often with eczema)	Congenital immunodeficiency syndrome (eg, IgA deficiency, hyper-IgE syndrome, Wiskott-Aldrich syndrome) Graft-vs-host disease
Acute leukemias and myeloproliferative neoplasms	Acute or chronic eosinophilic leukemia Acute lymphoblastic leukemia, particularly B-cell acute lymphoblastic leukemia (B-ALL) with t(5;14)(q31;q32) - IGH–IL3 rearrangement* Chronic myeloid leukemia Hypereosinophilic syndrome
Nonparasitic infections	Aspergillosis Brucellosis Cat-scratch disease Chlamydial pneumonia of infancy Coccidioidomycosis (acute) Infectious lymphocytosis Infectious mononucleosis Mycobacterial disease Scarlet fever
Parasitic infections (especially due to tissue-invasive metazoans)	Angiostrongyliasis Anisakiasis Ascariasis Clonorchiasis Cysticercosis (caused by Taenia solium) Echinococcosis Fascioliasis Filariasis Hookworm infection Paragonimiasis Pneumocystis jirovecii infection Schistosomiasis Strongyloidiasis Toxocariasis Trichinosis Trichuriasis
Skin disorders	Dermatitis herpetiformis Exfoliative dermatitis Pemphigus Psoriasis
Syndromes of pulmonary infiltration with eosinophilia	Allergic bronchopulmonary aspergillosis Chronic eosinophilic pneumonia Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) Löffler syndrome Tropical pulmonary eosinophilia
Non-myeloproliferative cancers	Angioimmunoblastic T-cell lymphoma (previously known as angioimmunoblastic lymphadenopathy with dysproteinemia or AILD) in association with systemic symptoms and autoimmune hemolytic anemia Carcinomas and sarcomas of the lung, pancreas, colon, cervix, or ovary Hodgkin lymphoma Non-Hodgkin lymphomas
Miscellaneous	Cirrhosis Familial eosinophilia Peritoneal dialysis Radiation therapy
* Fournier B, Balducci E, Duployez N, et al. B-ALL With t(5;14)(q31;q32); IGH-IL3 Rearrangement and Eosinophilia: A Comprehensive Analysis of a Peculiar IGH-Rearranged B-ALL. Front Oncol. 2019;9:1374. doi:10.3389/fonc.2019.01374
NSAID = nonsteroidal anti-inflammatory drug.