MSD Manual

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Introduction to Bullous Diseases


Daniel M. Peraza

, MD, Geisel School of Medicine at Dartmouth University

Last full review/revision Jan 2022| Content last modified Sep 2022
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Bullae are elevated, fluid-filled blisters ≥ 10 mm in diameter.

The autoimmune bullous diseases include

Epidermolysis bullosa Epidermolysis Bullosa Epidermolysis bullosa is a group of 4 very rare genetic diseases and their subtypes. Epithelial fragility and easy blistering of skin and mucous membranes usually manifest at birth or in infancy... read more Epidermolysis Bullosa is a group of inherited diseases in which epithelial adhesion protein defects lead to epithelial fragility and bullae formation. Epidermolysis bullosa acquisita is a similar bullous disease thought to be autoimmune, but it is not inherited.

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