Cancers of the mouth, nose, and throat develop in almost 65,000 people in the United States each year. These cancers are more common among men because male smokers continue to outnumber female smokers and because oral human papillomavirus (HPV) infection is more frequent in males. Most affected people are between the ages of 50 and 70. However, the cancers caused by HPV, which are primarily oropharyngeal cancers, occur more often in younger people.