Початковий вибір класу антигіпертензивних препаратів
Medication Class | Indications |
|---|---|
ACE inhibitors* | Youth Left ventricular failure due to systolic dysfunction† Albumin:creatinine ratio > 30 mg/gram (> 33.9 mg/mmol) in patients with chronic renal disorders or diabetic glomerulosclerosis Erectile dysfunction due to other medications |
Angiotensin II receptor blockers* | Youth Conditions for which ACE inhibitors are indicated but not tolerated because of cough or angioedema Diabetes with nephropathy Left ventricular failure with systolic dysfunction Secondary stroke |
Long-acting calcium channel blockers | Older age African or Black American ancestry Arrhythmias (eg, atrial fibrillation, paroxysmal supraventricular tachycardia) Isolated systolic hypertension in older patients (dihydropyridines)† High CAD risk (nondihydropyridines)† |
Thiazide-type diuretics† (chlorthalidone or indapamide) | Older age African or Black American ancestry |
* Contraindicated in pregnancy. | |
† Reduced morbidity and mortality rates in randomized studies. | |
ACE = angiotensin-converting enzyme; CAD = coronary artery disease. | |