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Risk Factors and Comorbidities Associated With Depression or Mania

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Type of Disorder	Depression	Mania
Systemic rheumatic disease	Systemic lupus erythematosus (SLE)	SLE
Endocrine	Addison disease Cushing syndrome Diabetes mellitus Hyperparathyroidism Hyperthyroidism Hypogonadism Hypopituitarism Hypothyroidism	Hyperthyroidism
Infectious	Advanced HIV infection General paresis (parenchymatous neurosyphilis) Infectious mononucleosis Influenza Tuberculosis (TB) Viral hepatitis Viral pneumonia	Advanced HIV infection General paresis Influenza St. Louis encephalitis
Neoplastic	Cancer of the head of the pancreas Disseminated carcinomatosis	—
Neurologic	Cerebral tumors Focal-onset seizures Dementing disorders in the early phase Head trauma Multiple sclerosis Parkinson disease Sleep apnea Stroke (left frontal)	Focal-onset seizures Diencephalic tumors Head trauma Huntington disease Multiple sclerosis Stroke
Nutritional	Pellagra Pernicious anemia	—
Other	Coronary artery disease Fibromyalgia Renal failure or hepatic failure	—
Pharmacologic	Amphetamine withdrawal Amphotericin B Anticholinesterase insecticides Barbiturates Beta-blockers (some, eg, propranolol) Cimetidine Corticosteroids Cycloserine Indomethacin Interferon Mercury Methyldopa Metoclopramide Estrogen-progestin contraceptives Phenothiazines Progestogens Reserpine Thallium Vinblastine Vincristine	Amphetamines Certain antidepressants Bromocriptine Cocaine Corticosteroids Levodopa Methylphenidate Sympathomimetic medications
Psychiatric (other than mood disorders)	Alcohol and other substance use disorders Antisocial personality disorder Anxiety disorders Borderline personality disorder Schizophrenic disorders	—