Cutaneous Penile Lesions

ByPatrick J. Shenot, MD, Thomas Jefferson University Hospital
Reviewed/Revised Aug 2023
View Patient Education

    Common skin disorders and infections can cause cutaneous penile lesions (see table Causes of Cutaneous Penile Lesions).

    Table

    Balanitis xerotica obliterans

    This lesion, another name for lichen sclerosus et atrophicus in men, is an indurated, blanched area near the tip of the glans surrounding and often constricting the meatus. It results from chronic inflammation and may lead to phimosis, paraphimosis, or urethral stricture

    Cutaneous Penile Lesions
    Balanitis Xerotica Obliterans
    Balanitis Xerotica Obliterans
    The area around the urethral meatus is indurated and blanched. Scratching and rubbing have resulted in irritation and p... read more

    © Springer Science+Business Media

    Balanitis Xerotica Obliterans With Meatal Occlusion
    Balanitis Xerotica Obliterans With Meatal Occlusion

    © Springer Science+Business Media

    Erythroplasia of Queyrat With Penile Carcinoma
    Erythroplasia of Queyrat With Penile Carcinoma
    This photo shows erythroplasia of Queyrat.

    © Springer Science+Business Media

    Erythroplasia of Queyrat With Carcinoma in Situ
    Erythroplasia of Queyrat With Carcinoma in Situ
    This photo shows squamous cell carcinoma in situ of the glans penis with a sharply demarcated, bright red, velvety plaq... read more

    © Springer Science+Business Media

    Lichen Planus (Penis)
    Lichen Planus (Penis)
    Annular lesion on the glans of the penis is consistent with lichen planus.

    DR P. MARAZZI/SCIENCE PHOTO LIBRARY

    Pearly Penile Papules and Penile Warts
    Pearly Penile Papules and Penile Warts
    This patient has a ring of pearly lesions along the corona of the glans (from left to lower right) consistent with pear... read more

    DR P. MARAZZI/SCIENCE PHOTO LIBRARY

    Carcinoma in situ

    Carcinoma in situ can include

    • Erythroplasia of Queyrat: Squamous cell carcinoma in situ of the glans or prepuce

    • Bowen disease of the penis: Squamous cell carcinoma in situ of the penile skin

    • Paget disease of the nipple

    • Bowenoid papulosis: Associated with human papillomavirus (particularly HPV types 16 and 18)

    Erythroplasia of Queyrat and Bowen disease of the penis are well-circumscribed areas of reddish, velvety pigmentation in the genital area, usually on the glans or at the corona, primarily in uncircumcised men.

    Paget disease of the nipple (not to be confused with Paget disease of bone) is a rare intraepithelial adenocarcinoma that can occur in extramammary locations, including the penis.

    Bowenoid papulosis involves smaller, often multiple papules on the shaft of the penis.

    These conditions are considered intraepithelial neoplasia or carcinoma in situ and should be biopsied.

    Penile lichen planus

    This lesion occurs as small plaques, papules or macules, sometimes annular, on the glans or shaft and may be mistaken for pemphigoid or erythema multiforme. Pruritus is common.

    Penogingival syndrome in men (and vulvovaginal gingival syndrome in women) is a more severe form of erosive lichen planus. It occurs on both oral and genital mucosa. Ulcers may develop and cause pain.

    Lichen planus usually resolves spontaneously. If asymptomatic, it may not require treatment. Topical corticosteroids may help relieve symptoms.

    Pearly penile papules

    These papules are small, harmless angiofibromas that appear on the corona of the penis as dome-shaped or hairlike projections and tend to be skin-colored. They may also appear on the distal shaft. They are common, occurring in up to 10% of men. They are not associated with human papillomavirus, although they may be mistaken for genital warts. Treatment is not required.

    Contact dermatitis of the penis

    Contact dermatitis of the penis has become more common with the widespread use of latex condoms. Dermatitis appears as red, pruritic lesions, sometimes with weeping or fissures. Treatment is with topical corticosteroids and use of nonlatex condoms (but not natural condoms, which do not provide adequate protection against HIV). Mild over-the-counter corticosteroids can be tried first, with use of middle- or high-potency prescription preparations as needed.

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