Деякі ліки та токсини, які можуть викликати жовтяницю
Mechanism | Medications or Toxins |
|---|---|
Increased bilirubin production | Medications that cause hemolysis (common among patients with glucose-6-phosphate dehydrogenase [G6PD] deficiency), such as sulfa drugs and nitrofurantoin |
Decreased hepatic uptake | Chloramphenicol, probenecid, rifampin |
Decreased conjugation | Ethinyl estradiol |
Hepatocellular dysfunction | Acetaminophen (high dose or overdose), amiodarone, isoniazid, nonsteroidal anti-inflammatory drugs, statins, many others, many medication combinations Amanita phalloides mushrooms, carbon tetrachloride, phosphorus (see Hydrocarbon Poisoning and Volatile Solvents) |
Intrahepatic cholestasis | Amoxicillin/clavulanate, anabolic steroids, chlorpromazine, pyrrolizidine alkaloids (eg, in herbal preparations), oral contraceptives, phenothiazines |