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Causes of an Enlarged Spleen

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Category	Specific Cause
Anemias	Hereditary elliptocytosis Hereditary spherocytosis Sickle cell disease (mainly in children) Thalassemia
Blood cancers and myeloproliferative neoplasms	Hodgkin lymphoma and other lymphomas Leukemia Myelofibrosis Polycythemia vera
Infections	Brucellosis Candidiasis Hepatitis Histoplasmosis Infectious mononucleosis Visceral leishmaniasis (kala-azar) Malaria Psittacosis Subacute bacterial endocarditis Syphilis Tuberculosis
Storage diseases	Gaucher disease Niemann-Pick disease Wolman disease
Other causes	Amyloidosis Blood clot in a vein from the spleen or to the liver Cirrhosis Cysts in the spleen External pressure on veins from the spleen or to the liver Felty syndrome (a subset of people with rheumatoid arthritis who also develop low white blood cell count and an enlarged spleen) Hemophagocytic lymphohistiocytosis Langerhans cell histiocytosis (formerly called Hand-Schüller-Christian disease and Letterer-Siwe disease) Sarcoidosis Systemic lupus erythematosus (lupus)