Tigecycline

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Most of the drug is excreted in bile and feces. No dosing adjustment is required in patients who have renal insufficiency.

• Many gram-positive bacteria, including methicillin-susceptible and methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniaeEnterococcus faecalis

• Many gram-negative bacteria, such as multidrug-resistant Acinetobacter baumannii, Stenotrophomonas maltophilia, beta-lactamase–negative Haemophilus influenzae, and most Enterobacterales (formerly Enterobacteriaceae; including some strains that produce extended-spectrum beta-lactamases [ESBLs] and other strains that were carbapenem-resistant based on production of a carbapenemase or metallo-beta-lactamase)

• Many atypical respiratory pathogens (chlamydiae, Mycoplasma species), Mycobacterium abscessus, M. fortuitum, and anaerobes, including Bacteroides fragilis, Clostridium perfringens, and Clostridioides difficile (formerly Clostridium difficile)

It is not effective against Pseudomonas aeruginosa, Providencia species, Morganella morganii, or Proteus species.

• Complicated skin and soft-tissue infections

• Complicated intra-abdominal infections

• Community-acquired pneumonia

ventilator-associated pneumoniaC. difficileC. difficile infection.

tetracyclines, can affect fetal bones and teeth. If a pregnant woman takes it during the 2nd or 3rd trimester, it may cause permanent discoloration of the fetus's teeth.

• Nausea, vomiting, and diarrhea

• Photosensitivity

• Hepatotoxicity

tetracyclines (eg, photosensitivity).

Dose is adjusted in patients with hepatic dysfunction but not in those with renal dysfunction.