Common causes include hepatitis B and C viruses and certain drugs.
Most people have no symptoms, but some have vague symptoms, such as a general feeling of illness, poor appetite, and fatigue.
Chronic hepatitis can progress to cirrhosis and ultimately liver cancer and/or liver failure.
A biopsy is sometimes done to confirm the diagnosis, but chronic hepatitis is usually diagnosed based on blood test results.
Drugs, such as antiviral drugs or corticosteroids, may be used, and for advanced disease, liver transplantation may be needed.
(See also Overview of Hepatitis Overview of Hepatitis Hepatitis is inflammation of the liver. (See also Overview of Acute Viral Hepatitis and Overview of Chronic Hepatitis.) Hepatitis is common throughout the world. Hepatitis can be Acute (short-lived) read more , Hepatitis B, Chronic Hepatitis B, Chronic Chronic hepatitis B is inflammation of the liver that is caused by the hepatitis B virus and that has lasted more than 6 months. Most people with chronic hepatitis B have no symptoms, but some... read more , and Hepatitis C, Chronic Hepatitis C, Chronic Chronic hepatitis C is inflammation of the liver that is caused by the hepatitis C virus and that has lasted more than 6 months. Hepatitis C often causes no symptoms until after it has badly... read more .)
Chronic hepatitis, although much less common than acute viral hepatitis Overview of Acute Viral Hepatitis Acute viral hepatitis is inflammation of the liver caused by infection with one of the five hepatitis viruses. In most people, the inflammation begins suddenly and lasts only a few weeks. Symptoms... read more , can persist for years, even decades. In many people, it is quite mild and does not cause significant liver damage. However, in some people, continued inflammation slowly damages the liver, eventually resulting in cirrhosis Cirrhosis of the Liver Cirrhosis is the widespread distortion of the liver's internal structure that occurs when a large amount of normal liver tissue is permanently replaced with nonfunctioning scar tissue. The... read more (severe scarring of the liver), liver failure Liver Failure Liver failure is severe deterioration in liver function. Liver failure is caused by a disorder or substance that damages the liver. Most people have jaundice (yellow skin and eyes), feel tired... read more , and sometimes liver cancer Hepatocellular Carcinoma Hepatocellular carcinoma is a cancer that begins in the liver cells and is the most common of the primary liver cancers. Having hepatitis B or hepatitis C or fatty liver disease, or drinking... read more .
Causes of Chronic Hepatitis
The most common causes of chronic hepatitis are
Hepatitis C virus causes about 60 to 70% of cases of chronic hepatitis, and at least 75% of acute hepatitis C cases become chronic.
About 5 to 10% of hepatitis B cases in adults, sometimes with hepatitis D Hepatitis D Hepatitis D virus is infection of the liver that occurs only in people who have hepatitis B. Hepatitis D can be spread by contact with blood and other body fluids. Coinfection with hepatitis... read more coinfection, become chronic. (Hepatitis D does not occur by itself. It occurs only as a coinfection with hepatitis B.) Acute hepatitis B becomes chronic in up to 90% of infected newborns and in 25 to 50% of young children.
Rarely, hepatitis E virus causes chronic hepatitis in people with a weakened immune system, such as those who are taking drugs to suppress the immune system after an organ transplant, who are taking drugs to treat cancer, or who have HIV infection.
Hepatitis A virus does not cause chronic hepatitis.
Nonalcoholic steatohepatitis Fatty Liver (a type of chronic inflammation of the liver) usually occurs in people with excess body weight (obesity), diabetes, and/or abnormal levels of cholesterol and other fats (lipids) in the blood. All of these conditions cause the body to synthesize more fat or process (metabolize) and excrete fat more slowly. As a result, fat accumulates and is then stored inside liver cells (called fatty liver Fatty Liver Fatty liver is an abnormal accumulation of certain fats (triglycerides) inside liver cells. People with fatty liver may feel tired or have mild abdominal discomfort but otherwise have no symptoms... read more ). Fatty liver can lead to chronic inflammation and eventually progress to cirrhosis Cirrhosis of the Liver Cirrhosis is the widespread distortion of the liver's internal structure that occurs when a large amount of normal liver tissue is permanently replaced with nonfunctioning scar tissue. The... read more . (Fatty liver due to any condition other than excessive consumption of alcohol is called nonalcoholic fatty liver disease.)
Alcohol, after being absorbed in the digestive tract, is usually processed (metabolized) in the liver. As alcohol is processed, substances that can damage the liver are produced. Alcohol-related liver disease typically occurs in people who drink heavily for many months or years. Alcohol-related liver disease is characterized by fatty liver and widespread liver inflammation that can result in the death of liver cells. If people continue drinking, scar tissue can form in the liver and may eventually replace a large amount of normal liver tissue, resulting in cirrhosis.
Less often, chronic hepatitis results from
Hemochromatosis Hemochromatosis Hemochromatosis is a hereditary disorder that causes the body to absorb too much iron, causing iron to build up in the body and damage organs. In the United States, over 1 million people have... read more (a hereditary disorder that causes the body to absorb too much iron)
A thyroid disorder
In children and young adults, Wilson disease Wilson Disease In Wilson disease, a rare hereditary disorder, the liver does not excrete excess copper into the bile as it normally does, resulting in accumulation of copper in the liver and liver damage.... read more (a rare hereditary disorder involving abnormal retention of copper in the liver)
In autoimmune hepatitis, the chronic inflammation resembles inflammation caused by the body attacking its own tissues (an autoimmune reaction Autoimmune Disorders An autoimmune disorder is a malfunction of the body's immune system that causes the body to attack its own tissues. What triggers autoimmune disorders is not known. Symptoms vary depending... read more ). Autoimmune hepatitis is more common among women than men.
Certain drugs can cause chronic hepatitis, particularly when they are taken for a long time. They include amiodarone, isoniazid, methotrexate, methyldopa, nitrofurantoin, and tamoxifen and rarely acetaminophen.
No one knows exactly why a particular virus or drug causes chronic hepatitis in some people but not in others or why the degree of severity varies.
Did You Know...
Symptoms of Chronic Hepatitis
In about two thirds of people, chronic hepatitis develops gradually, often without causing any symptoms of a liver disorder until cirrhosis occurs. In the remaining one third, it develops after a bout of acute viral hepatitis that persists or returns (often several weeks later).
Chronic hepatitis often causes general symptoms, such as a vague feeling of illness (malaise), poor appetite, and fatigue. Sometimes affected people also have a low-grade fever and some discomfort in the upper abdomen. Jaundice Jaundice in Adults In jaundice, the skin and whites of the eyes look yellow. Jaundice occurs when there is too much bilirubin (a yellow pigment) in the blood—a condition called hyperbilirubinemia. (See also Overview... read more (a yellow discoloration of the skin and whites of the eyes caused by deposits of excess bilirubin) is rare unless liver failure develops. Many people with chronic hepatitis have no symptoms.
Often, the first specific symptoms occur when liver disease has progressed and there is evidence of cirrhosis. Symptoms can include
An enlarged spleen
Small spiderlike blood vessels visible in the skin (called spider angiomas)
Redness of the palms
A tendency to bleed (coagulopathy)
Brain function deteriorates because the badly damaged liver cannot remove toxic substances from the blood as it normally does. These substances then build up in the blood and reach the brain. Normally, the liver removes them from the blood, breaks them down, then excretes them as harmless by-products into the bile (the greenish yellow fluid that aids in digestion) or blood (see Functions of the Liver Functions of the Liver ). Treatment of hepatic encephalopathy can prevent the deterioration of brain function from becoming permanent.
Blood cannot clot as it normally does because the damaged liver can no longer synthesize enough of the proteins that help blood clot.
A few people have jaundice Jaundice in Adults In jaundice, the skin and whites of the eyes look yellow. Jaundice occurs when there is too much bilirubin (a yellow pigment) in the blood—a condition called hyperbilirubinemia. (See also Overview... read more , itchiness, and light-colored stools. Jaundice and itchiness develop because the damaged liver cannot remove bilirubin from the blood as it normally does. Bilirubin then builds up in the blood and is deposited in the skin. Bilirubin is a yellow pigment produced as a waste product during the normal breakdown of red blood cells. Stool is light-colored because the flow of bile out of the liver is blocked and less bilirubin is eliminated in stool. Bilirubin is what gives stool its typical brown color.
Autoimmune hepatitis may cause other symptoms that involve other body systems. Symptoms can include cessation of menstrual periods, joint pain and swelling, loss of appetite, and nausea. People with autoimmune hepatitis may also have other autoimmune disorders such as type 1 diabetes mellitus, ulcerative colitis, celiac disease, or autoimmune disorders that cause anemia or inflammation of the thyroid gland or kidneys.
In many people, chronic hepatitis does not progress for years. In others, it gradually worsens. The outlook depends partly on which virus is the cause and whether treatment is available:
Chronic hepatitis C, if untreated, causes cirrhosis in about 20 to 30% of people. However, cirrhosis may take decades to develop. The risk of liver cancer is increased usually only if cirrhosis is present.
Chronic hepatitis B tends to worsen, sometimes rapidly but sometimes over decades, leading to cirrhosis. Chronic hepatitis B also increases the risk of liver cancer Primary Liver Cancers Primary liver cancers are cancers that originate in the liver. The most common is hepatocellular carcinoma (hepatoma). At first, liver cancer usually causes only vague symptoms (such as weight... read more whether cirrhosis develops or not. (In people with liver disease caused by other conditions, liver cancer is usually a risk only if cirrhosis develops.) Rarely, chronic hepatitis B resolves on its own, without treatment.
Chronic coinfection with hepatitis B and D, if untreated, causes cirrhosis in up to 70%.
Autoimmune hepatitis can be effectively treated in most people, but some develop cirrhosis.
Chronic hepatitis caused by a drug often completely resolves once the drug is stopped.
Diagnosis of Chronic Hepatitis
Occasionally a biopsy
Doctors may suspect chronic hepatitis when
People have typical symptoms.
Blood tests (done for other reasons) detect elevated liver enzymes.
People have had acute hepatitis before.
Also, everyone aged 18 or over, regardless of whether symptoms are present, should be tested at least once for hepatitis C. Such testing is recommended because hepatitis C is often unrecognized.
Testing for chronic hepatitis usually begins with blood tests to measure the levels of liver enzymes and other substances produced by the liver (liver tests Liver Blood Tests Liver tests are blood tests that represent a noninvasive way to screen for the presence of liver disease (for example, hepatitis in donated blood) and to measure the severity and progress of... read more ). These tests may help establish or exclude the diagnosis of hepatitis, identify the cause, and determine the severity of liver damage.
Blood tests are also done to help doctors identify whether a hepatitis virus is causing the infection. If no virus is identified, other blood tests are needed to check for other causes, such as autoimmune hepatitis.
A liver biopsy Biopsy of the Liver Doctors can obtain a sample of liver tissue during exploratory surgery, but more often they obtain a sample by inserting a hollow needle through the person's skin and into the liver. This type... read more is sometimes done to confirm the diagnosis. The liver biopsy also enables a doctor to do the following:
Determine how severe the inflammation is
Determine whether any scarring (fibrosis Fibrosis of the Liver Fibrosis is the formation of an abnormally large amount of scar tissue in the liver. It occurs when the liver attempts to repair and replace damaged cells. Many conditions can damage the liver... read more ) or cirrhosis has developed
Possibly help identify the cause of hepatitis
Other tests may be done to determine how badly the liver is damaged and to check for other liver problems. Tests may include
Specialized imaging tests, such as ultrasound elastography and magnetic resonance elastography Diagnosis
Blood tests to measure substances (called markers) that indicate whether and how much fibrosis is present
Ultrasound elastography and magnetic resonance elastography use sound waves, applied to the abdomen, to determine how stiff the liver tissue is.
Screening for liver cancer
If people have chronic hepatitis B (or cirrhosis due to any liver disorder), screening for liver cancer is done every 6 months. Two tests are used:
Sometimes measurement of the level of alpha-fetoprotein in the blood
The level of alpha-fetoprotein—a protein normally produced by immature liver cells in fetuses—may be elevated when liver cancer is present.
Treatment of Chronic Hepatitis
Treatment of the cause (such as antiviral drugs for hepatitis B or C)
Treatment of complications
Treatment of chronic hepatitis focuses on treating the cause and managing the complications, such as ascites Treatment Ascites is the accumulation of protein-containing (ascitic) fluid within the abdomen. Many disorders can cause ascites, but the most common is high blood pressure in the veins that bring blood... read more and hepatic encephalopathy Treatment Hepatic encephalopathy is deterioration of brain function that occurs in people with severe liver disease because toxic substances normally removed by the liver build up in the blood and reach... read more , in people with cirrhosis.
If a drug is the cause, the drug is stopped. If another disorder is the cause, it is treated. If the cause is alcohol-related liver disease Treatment Alcohol-related liver disease is liver damage caused by drinking too much alcohol for a long time. In general, the amount of alcohol consumed (how much, how often, and for how long) determines... read more , doctors recommend changes in lifestyle, mainly abstinence from alcohol.
Hepatitis B and C
If chronic hepatitis B Hepatitis B, Chronic Chronic hepatitis B is inflammation of the liver that is caused by the hepatitis B virus and that has lasted more than 6 months. Most people with chronic hepatitis B have no symptoms, but some... read more is worsening or if liver enzyme levels are high, people are usually given antiviral drugs.
In some people, hepatitis B tends to recur once drug treatment is stopped and may be even more severe. Thus, these people may need to take an antiviral drug indefinitely.
With chronic hepatitis C Hepatitis C, Chronic Chronic hepatitis C is inflammation of the liver that is caused by the hepatitis C virus and that has lasted more than 6 months. Hepatitis C often causes no symptoms until after it has badly... read more , treatment with antiviral drugs is recommended for all unless their life expectancy is very short. Treatment can last from 8 to 24 weeks. Treating hepatitis C can eliminate the virus from the body and thus stop inflammation and prevent scarring and progression to cirrhosis.
Treatment of nonalcoholic steatohepatitis focuses on managing the conditions that contribute to it. For example, treatment may include
Eating a healthy diet (which can help control weight, diabetes, and possibly lipid levels)
Not taking drugs that can contribute to the disorder (such as tamoxifen, corticosteroids, and synthetic estrogens)
Avoiding toxins, such as pesticides
Usually, corticosteroids (such as prednisone or budesonide) are used to treat autoimmune hepatitis along with azathioprine, a drug used to suppress the immune system. These drugs suppress the inflammation, relieve symptoms, and improve long-term survival. Nevertheless, scarring in the liver may gradually worsen.
Stopping these drugs usually leads to recurrence of the inflammation, so most people have to take the drugs indefinitely. However, taking corticosteroids for a long time can have significant side effects. So doctors usually gradually reduce the dose of the corticosteroid so that people can stop taking it. People then take azathioprine or mycophenolate (other drugs that suppress the immune system) indefinitely.
Treatment of complications
Regardless of the cause or type of chronic hepatitis, cirrhosis Cirrhosis of the Liver Cirrhosis is the widespread distortion of the liver's internal structure that occurs when a large amount of normal liver tissue is permanently replaced with nonfunctioning scar tissue. The... read more , liver failure Treatment Liver failure is severe deterioration in liver function. Liver failure is caused by a disorder or substance that damages the liver. Most people have jaundice (yellow skin and eyes), feel tired... read more , and their complications require treatment.
Treating ascites Treatment Ascites is the accumulation of protein-containing (ascitic) fluid within the abdomen. Many disorders can cause ascites, but the most common is high blood pressure in the veins that bring blood... read more involves restricting salt consumption and taking a drug that helps the kidneys excrete more sodium and water into the urine (a diuretic).
Treating hepatic encephalopathy Treatment Hepatic encephalopathy is deterioration of brain function that occurs in people with severe liver disease because toxic substances normally removed by the liver build up in the blood and reach... read more involves taking drugs to help the body eliminate the toxic substances that can cause the brain function to deteriorate.
Liver transplantation Liver Transplantation Liver transplantation is the surgical removal of a healthy liver or sometimes a part of a liver from a living person and then its transfer into a person whose liver no longer functions. (See... read more may be considered for people with severe liver failure.