A doctor can often diagnose a musculoskeletal disorder based on the history and the results of a physical examination Physical Examination The musculoskeletal system comprises bones, muscles, joints, ligaments, tendons, and bursae (see Introduction to Biology of the Musculoskeletal System). Any of these components can be injured... read more . Laboratory tests Laboratory Tests A doctor can often diagnose a musculoskeletal disorder based on the history and the results of a physical examination. Laboratory tests, imaging tests, or other diagnostic procedures are sometimes... read more , imaging tests Imaging Tests A doctor can often diagnose a musculoskeletal disorder based on the history and the results of a physical examination. Laboratory tests, imaging tests, or other diagnostic procedures are sometimes... read more , or other diagnostic procedures Other Diagnostic Procedures A doctor can often diagnose a musculoskeletal disorder based on the history and the results of a physical examination. Laboratory tests, imaging tests, or other diagnostic procedures are sometimes... read more are sometimes necessary to help the doctor make or confirm a diagnosis.
Laboratory tests are often helpful in making the diagnosis of a musculoskeletal disorder. For example, blood tests are done to measure the level of C-reactive protein (CRP) in the blood and the erythrocyte sedimentation rate (ESR), the rate at which red blood cells settle to the bottom of a test tube containing blood. The ESR and the CRP are usually increased when inflammation is present. However, because inflammation occurs in so many conditions, both the ESR and the CRP levels alone do not establish a diagnosis.
The level of creatine kinase (a normal muscle enzyme that leaks out and is released into the bloodstream when muscle is damaged) may also be tested. Levels of creatine kinase are increased when there is widespread ongoing destruction of muscle.
In rheumatoid arthritis Diagnosis Rheumatoid arthritis is an inflammatory arthritis in which joints, usually including those of the hands and feet, are inflamed, resulting in swelling, pain, and often destruction of joints.... read more , a blood test to identify rheumatoid factor or anti-cyclic citrullinated peptide (anti-CCP) antibody is helpful in making the diagnosis.
In systemic lupus erythematosus Diagnosis Systemic lupus erythematosus is a chronic autoimmune inflammatory connective tissue disorder that can involve joints, kidneys, skin, mucous membranes, and blood vessel walls. Problems in the... read more (SLE or lupus), blood tests to identify autoimmune antibodies (autoantibodies), such as antinuclear antibodies and antibodies to double-stranded deoxyribonucleic acid (DNA), help in making the diagnosis.
A blood test can be done to identify people who have a certain gene (HLA-B27). People who have this gene are at increased risk of developing spondyloarthritis Overview of Spondyloarthritis Spondyloarthritis (also called spondyloarthropathy or spondyloarthritides) is a term used to describe a group of diseases that cause prominent joint inflammation, affect the spine and other... read more , a group of disorders that can cause inflammation of the back and other joints as well as other symptoms, such as eye pain and redness and rashes.
Some laboratory tests are also often useful to help monitor the progress of treatment. For example, the ESR can be particularly useful in helping to monitor the progress of treatment in rheumatoid arthritis Diagnosis Rheumatoid arthritis is an inflammatory arthritis in which joints, usually including those of the hands and feet, are inflamed, resulting in swelling, pain, and often destruction of joints.... read more or polymyalgia rheumatica Polymyalgia Rheumatica Polymyalgia rheumatica involves inflammation of the lining of joints, causing severe pain and stiffness in the muscles of the neck, back, shoulders, and hips. The cause is unknown. The neck... read more . A decrease in the ESR suggests that treatment is working to reduce inflammation.
Various types of imaging tests can help doctors diagnose musculoskeletal disorders.
X-rays X-Rays X-rays are a type of medical imaging that use very low-dose radiation waves to take pictures of bones and soft tissues. X-rays may be used alone (conventional x-ray imaging) or combined with... read more are typically done first. They are most valuable for detecting abnormalities in bone and are taken to evaluate painful, deformed, or suspected abnormal areas of bone. Often, x-rays can help to diagnose fractures Overview of Fractures A fracture is a crack or break in a bone. Most fractures result from force applied to a bone. Fractures usually result from injuries or overuse. The injured part hurts (especially when it is... read more , tumors Overview of Bone Tumors Bone tumors are growths of abnormal cells in bones. Bone tumors may be cancerous (malignant) or noncancerous (benign). Cancerous tumors may start in the bone (primary cancer) or start in other... read more , injuries, infections Osteomyelitis Osteomyelitis is a bone infection usually caused by bacteria, mycobacteria, or fungi. Bacteria, mycobacteria, or fungi can infect bones by spreading through the bloodstream or, more often, by... read more , and deformities (such as developmental dysplasia of the hip Developmental Dysplasia of the Hip Developmental dysplasia of the hip is a birth defect in which the bones in the hip are incorrectly developed. Birth defects, also called congenital anomalies, are physical abnormalities that... read more ). Also, sometimes x-rays are helpful in showing changes that confirm a person has a certain kind of arthritis (for example, rheumatoid arthritis Diagnosis Rheumatoid arthritis is an inflammatory arthritis in which joints, usually including those of the hands and feet, are inflamed, resulting in swelling, pain, and often destruction of joints.... read more or osteoarthritis Diagnosis Osteoarthritis is a chronic disorder that causes damage to the cartilage and surrounding tissues and is characterized by pain, stiffness, and loss of function. Arthritis due to damage of joint... read more ). X-rays do not show soft tissues such as muscles, bursae, ligaments, tendons, or nerves.
To help determine whether the joint has been damaged by injury, a doctor may use an ordinary (non-stress) x-ray or one taken with the joint under stress caused by certain positions (stress x-ray).
Arthrography is an x-ray procedure in which a radiopaque dye is injected into a joint space to outline the structures, such as ligaments inside the joint. Arthrography can be used to view torn ligaments and fragmented cartilage in the joint. However, magnetic resonance imaging Computed tomography (CT) and magnetic resonance imaging (MRI) A doctor can often diagnose a musculoskeletal disorder based on the history and the results of a physical examination. Laboratory tests, imaging tests, or other diagnostic procedures are sometimes... read more (MRI) is now generally used in preference to arthrography.
Bone scanning (a type of radionuclide scanning Radionuclide Scanning Radionuclide scanning is a type of medical imaging that produces images by detecting radiation after a radioactive material is administered. During a radionuclide scan, a small amount of a radionuclide... read more ) is an imaging procedure that is occasionally used to diagnose a fracture, particularly if other tests, such as plain x-rays and computed tomography (CT) or magnetic resonance imaging (MRI), do not reveal the fracture. Bone scanning involves use of a radioactive substance (technetium-99m–labeled pyrophosphate) that is absorbed by any healing bone. The procedure can also be done when a bone infection or a tumor that has spread from a cancer elsewhere in the body is suspected.
Although a bone scan may show a problem in the bone, it may not show whether the problem is a fracture, tumor, or infection. The radioactive substance is given by vein (intravenously) and is detected by a bone-scanning device, which creates an image of the bone that can be viewed on a computer screen.
Computed tomography (CT) and magnetic resonance imaging (MRI)
Computed tomography Computed Tomography (CT) Computed tomography (CT) is a type of medical imaging that combines a series of x-rays to create cross-sectional, detailed images of internal structures. In computed tomography (CT), which used... read more (CT) and magnetic resonance imaging Magnetic Resonance Imaging (MRI) Magnetic resonance imaging (MRI) is a type of medical imaging that uses a strong magnetic field and very high frequency radio waves to produce highly detailed images. During an MRI, a computer... read more (MRI) give much more detail than plain x-rays and may be done to determine the extent and exact location of damage. These tests can also be used to detect fractures that are not visible on x-rays.
MRI is especially valuable for imaging muscles, ligaments, and tendons. MRI can be used if the cause of pain is thought to be a severe soft-tissue problem (for example, rupture of a major ligament or tendon or damage to important structures inside the knee joint).
CT is useful if MRI is unavailable or not recommended. CT exposes people to ionizing radiation (see Risks of Radiation in Medical Imaging Risks of Radiation in Medical Imaging Imaging tests that use radiation, usually x-rays, are a valuable tool in diagnosis, but exposure to radiation has some risks (see also Radiation Injury). Different diagnostic tests require different... read more ). CT best images bone compared with other structures. However, MRI is better than CT for imaging some bone abnormalities, such as small fractures of the hip and pelvis. The amount of time a person spends undergoing CT is much less than for MRI. MRI is more expensive than CT and, with the exception of when the open-sided units are used, many people feel claustrophobic inside the MRI unit.
Dual-energy x-ray absorptiometry (DXA)
The most accurate way to evaluate bone density is with dual-energy x-ray absorptiometry (DXA). DXA is necessary when screening for or diagnosing osteopenia (reduced bone density) or its progression to osteoporosis Bone density testing Osteoporosis is a condition in which a decrease in the density of bones weakens the bones, making breaks (fractures) likely. Aging, estrogen deficiency, low vitamin D or calcium intake, and... read more . DXA is also used to predict a person's risk of fracture and can be useful for monitoring the response to treatment as well. This test is quick and painless and involves very little radiation.
In this test, x-rays are used to examine bone density at the lower spine, hip, wrist, or entire body. Measurements of bone density are very accurate at these sites. When screening people for osteoporosis Bone density testing Osteoporosis is a condition in which a decrease in the density of bones weakens the bones, making breaks (fractures) likely. Aging, estrogen deficiency, low vitamin D or calcium intake, and... read more , doctors prefer taking measurements of the lower spine and hip. To help differentiate osteoporosis (the most common cause of an abnormal DXA scan result) from other bone disorders, doctors may need to consider the person's symptoms, medical conditions, medications, and certain blood or urine test results as well as the DXA results.
Ultrasonography Ultrasonography Ultrasonography is a type of medical imaging that uses high-frequency sound (ultrasound) waves to produce images of internal organs and other tissues. During an ultrasound, a device called a... read more is being used more and more frequently to identify abnormalities and inflammation in and around joints and tears or inflammation of tendons. Ultrasonography is also used as a guide when a needle needs to be put into a joint (for example, to inject medications or to remove joint fluid). As an alternative to computed tomography Computed Tomography (CT) Computed tomography (CT) is a type of medical imaging that combines a series of x-rays to create cross-sectional, detailed images of internal structures. In computed tomography (CT), which used... read more (CT) and magnetic resonance imaging Magnetic Resonance Imaging (MRI) Magnetic resonance imaging (MRI) is a type of medical imaging that uses a strong magnetic field and very high frequency radio waves to produce highly detailed images. During an MRI, a computer... read more (MRI), ultrasonography is less expensive and, unlike CT, involves no exposure to radiation.
Other Diagnostic Procedures
Other procedures and tests are sometimes needed to help doctors diagnose musculoskeletal disorders.
Arthroscopy is a procedure in which a small (diameter of a pencil) fiberoptic scope is inserted into a joint space, allowing the doctor to look inside the joint and to project the image onto a video monitor. The skin incision is very small. This procedure is done in a hospital or surgical center. The person is given local, spinal, or general anesthesia Anesthesia Surgery is the term traditionally used to describe procedures (called surgical procedures) that involve manually cutting or stitching tissue to treat diseases, injuries, or deformities. However... read more or a combination.
During arthroscopy, doctors can take a piece of tissue (such as joint cartilage or the joint capsule) for analysis (biopsy), and, if necessary, do surgery to correct the condition. Disorders commonly found during arthroscopy include
Inflammation of the synovium lining the joint (synovitis)
Ligament, tendon, or cartilage tears
Loose pieces of bone or cartilage
Such conditions affect people with arthritis or previous joint injuries as well as athletes. Most of these conditions can be repaired or removed during arthroscopy. There is a very small risk of joint infection with this procedure.
Recovery time after arthroscopic surgery is much faster than after traditional surgery. Most people do not need to stay overnight in the hospital.
Joint aspiration (arthrocentesis)
Joint aspiration is used to diagnose certain joint problems. For example, it is the most direct and accurate way to determine whether joint pain and swelling is caused by an infection or crystal-related arthritis (such as gout Diagnosis Gout is a disorder in which deposits of uric acid crystals accumulate in the joints because of high blood levels of uric acid (hyperuricemia). The accumulations of crystals cause flares (attacks)... read more ).
For this procedure, a doctor first injects an anesthetic to numb the area. Then the doctor inserts a larger needle into the joint space (sometimes guided by ultrasonography), draws out (aspirates) joint fluid (synovial fluid), and examines the fluid under a microscope. A doctor removes as much fluid as possible and notes its color and clarity. Other tests, such as white blood cell count and culture, are done on the fluid.
The doctor can often make a diagnosis after analyzing the fluid. For example, a sample of fluid may contain bacteria, which confirm a diagnosis of infection. Or, it may contain certain crystals. For example, finding uric acid crystals confirms a diagnosis of gout Diagnosis Gout is a disorder in which deposits of uric acid crystals accumulate in the joints because of high blood levels of uric acid (hyperuricemia). The accumulations of crystals cause flares (attacks)... read more , and calcium pyrophosphate dihydrate crystals confirm a diagnosis of calcium pyrophosphate arthritis (pseudogout Calcium Pyrophosphate (CPP) Arthritis Calcium pyrophosphate (CPP) arthritis (previously called pseudogout) is a disorder caused by deposits of calcium pyrophosphate dihydrate crystals in the joint cartilage, leading to intermittent... read more ).
Usually done in the doctor's office or an emergency department, this procedure is typically quick, easy, and relatively painless. The risk of joint infection is minimal.
Nerve and muscle tests
Nerve conduction studies Nerve conduction studies Diagnostic procedures may be needed to confirm a diagnosis suggested by the medical history and neurologic examination. Imaging tests commonly used to diagnose nervous system (neurologic) disorders... read more help determine whether the nerves supplying the muscles are functioning normally. Electromyography Electromyography Diagnostic procedures may be needed to confirm a diagnosis suggested by the medical history and neurologic examination. Imaging tests commonly used to diagnose nervous system (neurologic) disorders... read more , usually done at the same time as nerve conduction studies, is a test in which electrical impulses in the muscles are recorded to help determine how well the impulses from the nerves are reaching the connection between nerves and muscles (neuromuscular junction) and, from there, the muscles.
Nerve conduction studies, together with electromyography, help indicate whether there is a problem primarily in the
Muscles Muscles There are three types of muscles: Skeletal Smooth Cardiac (heart) Two of these kinds—skeletal and smooth—are part of the musculoskeletal system. read more (such as myositis Autoimmune Myositis Autoimmune myositis causes inflammation and weakness in the muscles (polymyositis) or in the skin and muscles (dermatomyositis). Muscle damage may cause muscle pain and muscle weakness may cause... read more or muscular dystrophy Introduction to Muscular Dystrophies and Related Disorders Muscular dystrophies are a group of inherited muscle disorders in which one or more genes needed for normal muscle structure and function are defective, leading to muscle weakness of varying... read more )
Nervous system Overview of the Nervous System The nervous system has 2 distinct parts: the central nervous system (the brain and spinal cord) and the peripheral nervous system (the nerves outside the brain and spinal cord). The basic unit... read more (the brain, spinal cord, and nerves), which controls the muscles (such as a stroke Overview of Stroke A stroke occurs when an artery to the brain becomes blocked or ruptures, resulting in death of an area of brain tissue due to loss of its blood supply (cerebral infarction). Symptoms occur suddenly... read more , spinal cord problem Overview of Spinal Cord Disorders Spinal cord disorders can cause permanent severe problems, such as paralysis or impaired bladder and bowel control ( urinary incontinence and fecal incontinence). Sometimes these problems can... read more , or polyneuropathy Polyneuropathy Polyneuropathy is the simultaneous malfunction of many peripheral nerves throughout the body. Infections, toxins, drugs, cancers, nutritional deficiencies, diabetes, autoimmune disorders, and... read more )
Neuromuscular junction Overview of Neuromuscular Junction Disorders Nerves connect with muscles at the neuromuscular junction. There, the ends of nerve fibers connect to special sites on the muscle’s membrane called motor end plates. These plates contain receptors... read more (such as myasthenia gravis Myasthenia Gravis Myasthenia gravis is an autoimmune disorder that impairs communication between nerves and muscles, resulting in episodes of muscle weakness. Myasthenia gravis results from malfunction of the... read more )
Nerve conduction studies are particularly useful for the diagnosis of peripheral nerve disorders Overview of the Peripheral Nervous System The peripheral nervous system refers to the parts of the nervous system that are outside the central nervous system, that is, those outside the brain and spinal cord. Thus, the peripheral nervous... read more , such as carpal tunnel syndrome Carpal Tunnel Syndrome Carpal tunnel syndrome is a painful compression (pinching) of the median nerve as it passes through the carpal tunnel in the wrist. The cause of most cases of carpal tunnel syndrome is unknown... read more and ulnar nerve palsy Ulnar nerve palsy Mononeuropathy is damage to a single peripheral nerve. Pressure on a nerve for a long time is the most common cause of mononeuropathy. The affected area may tingle, feel prickly, or be numb... read more .