Набряк губ

Spontaneous (ie, nontraumatic) lip swelling is usually painless. Itching may or may not be present. Cheilitis sometimes causes lip swelling, but patients typically present because of the painful inflammation and lesions.

In isolation, lip swelling is not dangerous. However, when lip swelling is caused by angioedema, concurrent swelling in the oropharynx and/or lower airways can be fatal.

Lip swelling may be acute or chronic.

Acute lip swelling may be caused by:

• Allergic reactions (eg, to foods, medications, illicit drugs or substances, lipstick, airborne irritants, nickel)

• Environmental factors (eg, cold and dry weather, sunburn)

• Hereditary angioedema

• Nonallergic medication causes (eg, angiotensin-converting enzyme [ACE] inhibitors, calcium channel blockers, certain fibrinolytic agents)

Зображення ангіоневротичного набряку губ та язика

Спадковий ангіоневротичний набряк

This photo shows acute swelling of the lips in a patient with hereditary C1 inhibitor deficiency.

This photo shows acute swelling of the lips in a patient with hereditary C1 inhibitor deficiency.

By permission of the publisher. From Joe E, Soter N. In Current Dermatologic Diagnosis and Treatment, edited by I Freedberg, IM Freedberg, and MR Sanchez. Philadelphia, Current Medicine, 2001.

Ангіоневротичний набряк губ

Angioedema of the lips can be asymmetric, as shown in this photo.

Angioedema of the lips can be asymmetric, as shown in this photo.

DR P. MARAZZI/SCIENCE PHOTO LIBRARY

Ангіоневротичний набряк язика

SCIENCE PHOTO LIBRARY

Спадковий ангіоневротичний набряк

This photo shows acute swelling of the lips in a patient with hereditary C1 inhibitor deficiency.

This photo shows acute swelling of the lips in a patient with hereditary C1 inhibitor deficiency.

By permission of the publisher. From Joe E, Soter N. In Current Dermatologic Diagnosis and Treatment, edited by I Freedberg, IM Freedberg, and MR Sanchez. Philadelphia, Current Medicine, 2001.

Ангіоневротичний набряк губ

Angioedema of the lips can be asymmetric, as shown in this photo.

Angioedema of the lips can be asymmetric, as shown in this photo.

DR P. MARAZZI/SCIENCE PHOTO LIBRARY

Ангіоневротичний набряк язика

SCIENCE PHOTO LIBRARY

Chronic lip swelling may occur with:

• Acromegaly (often with enlarged facial features and/or tongue from glycosaminoglycan accumulation) (1)

• Hypothyroidism (often with facial edema and/or enlarged tongue) (2)

Rare causes of chronic lip swelling include ongoing exposure to an unsuspected allergen, cheilitis granulomatosa (3), and Crohn disease (4).

The first step in evaluation is to assess airway patency and establish and control the airway if necessary. Diagnostic inquiry focuses on potential causative exposures and underlying diseases.

Treatment includes elimination of identified causes and treatment of causative diseases. Glucocorticoid ointment or antihistamines (eg, diphenhydramine) may be used for allergic lip swelling. Surgical removal of chronic excess lip tissue may have cosmetic benefit.