Advanced HIV-Related Illnesses

• Bacterial infections, multiple or recurrent*

• Candidiasis of bronchi, trachea, or lungs

• Candidiasis of esophagus

• Cervical cancer, invasive†

• Coccidioidomycosis, disseminated or extrapulmonary

• Cryptococcosis, extrapulmonary

• Cryptosporidiosis, chronic intestinal (lasting > 1 month)

• Cytomegalovirus disease (other than liver, spleen, or lymph nodes), onset at age > 1 month

• Cytomegalovirus retinitis (with loss of vision)

• Encephalopathy attributed to HIV

• Herpes simplex virus: Chronic ulcers (lasting > 1 month) or bronchitis, pneumonitis, or esophagitis (onset at age > 1 month)

• Histoplasmosis, disseminated or extrapulmonary

• Isosporiasis (cystoisosporiasis), chronic intestinal (lasting > 1 month)

• Kaposi sarcoma

• Lymphoma, Burkitt (or equivalent term)

• Lymphoma, immunoblastic (or equivalent term)

• Lymphoma, primary, of brain

• Mycobacterium avium complex (MAC) or M. kansasii, disseminated or extrapulmonary

• Mycobacterium tuberculosis of any site, pulmonary, disseminated, or extrapulmonary

• Mycobacterium, other species or unidentified species, disseminated or extrapulmonary

• Pneumocystis jirovecii pneumonia

• Pneumonia, recurrent†

• Progressive multifocal leukoencephalopathy (PML)

• Salmonella septicemia, recurrent

• Toxoplasmosis of brain, onset at age > 1 month

• Wasting syndrome attributed to HIV infection

* Only among children aged < 6 years; not applicable to older children or adults because of limited specificity.

† Only among patients aged ≥ 6 years.

Data from Guidelines for Managing Advanced HIV Disease and Rapid Initiation of Antiretroviral Therapy. Geneva: World Health Organization. July 2017.