Linezolid
Staphylococci, including methicillin-resistant S. aureus (MRSA) and other strains resistant to other classes of antibiotics
Mycobacteria, including Mycobacterium tuberculosis
Anaerobes, such as Fusobacterium, Prevotella, Porphyromonas, and Bacteroides species and peptostreptococci
Serotonin syndrome
serotonin syndrome (a hyperserotonergic state characterized by mental status changes, neurologic abnormalities, and autonomic instability) when it is used in patients with either of the following:
Endocrinologically active carcinoid tumors
Use of drugs with serotonergic activity
Promptly stop the proserotonergic drug
Hypertension
Those with uncontrolled hypertension
Those with thyrotoxicosis
Those with a pheochromocytoma
Use During Pregnancy and Breastfeeding
Reversible myelosuppression
Irreversible peripheral neuropathy
Reversible optic neuropathy
Reversible myelosuppression, including thrombocytopenia, leukopenia, and anemia, occurs in about 3% of patients, usually when therapy is used > 2 weeks. Consequently, complete blood count is monitored weekly, especially when therapy lasts > 2 weeks.
