MSD Manual

Please confirm that you are a health care professional

honeypot link

Quinupristin and Dalfopristin

By

Brian J. Werth

, PharmD, University of Washington School of Pharmacy

Last full review/revision May 2022| Content last modified Sep 2022
Click here for Patient Education

Quinupristin/dalfopristin (Q/D) is given together in a fixed 30/70 combination; this combination has synergistic bactericidal activity against the following:

Q/D is given via a central IV catheter because phlebitis frequently occurs when Q/D is given via a peripheral vein. Up to 30% of patients develop significant myalgias. Q/D may cause hyperbilirubinemia.

Dosage reduction is required for severe hepatic insufficiency but not for renal insufficiency.

Safety Warning

Q/D may inhibit the metabolism of drugs that are metabolized by the cytochrome P-450 (CYP450) 3A4 isoenzyme system.

Click here for Patient Education
NOTE: This is the Professional Version. CONSUMERS: Click here for the Consumer Version
quiz link

Test your knowledge

Take a Quiz! 
iOS ANDROID
iOS ANDROID
iOS ANDROID
TOP