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Tables

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Cause	Examples
Platelet disorders
Decreased number of platelets	Aplastic anemia Cirrhosis if the spleen is also enlarged DIC if it progresses rapidly Hemolytic-uremic syndrome HIV infection Immune thrombocytopenia Leukemia Medications that can trigger destruction of platelets (including heparin, quinidine, quinine, sulfonamides, sulfonylureas, or rifampin) Thrombotic thrombocytopenic purpura
Increased number of platelets (which often causes excessive clotting but sometimes causes excessive bleeding)	Primary thrombocythemia
Inadequate platelet function	Chronic kidney disease Medications that can cause platelets to malfunction (including aspirin or other NSAIDs) Multiple myeloma von Willebrand disease
Clotting disorders
Acquired	Anticoagulants (medications that inhibit clotting) including heparin, warfarin, or DOACs (including dabigatran, apixaban, edoxaban, and rivaroxaban) DIC if it progresses slowly Liver disease Vitamin K deficiency
Hereditary	Hemophilia von Willebrand disease
Blood vessel disorders
Acquired	Immunoglobulin A–associated vasculitis Vitamin C deficiency
Hereditary	Connective tissue disorders (such as Marfan syndrome) Hereditary hemorrhagic telangiectasia
DIC = disseminated intravascular coagulation; DOAC = direct oral anticoagulant; HIV = human immunodeficiency virus; NSAIDs = nonsteroidal anti-inflammatory drugs.