Ugonjwa wa Kukusanyika kwa Fuwele za Kalsiamu Fosfati ya Msingi (BCP)

NaSarah F. Keller, MD, MA, Cleveland Clinic, Department of Rheumatic and Immunologic Diseases
Imekaguliwa naBrian F. Mandell, MD, PhD, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University
Imepitiwa/Imerekebishwa Imebadilishwa Jul 2025
v8524042_sw

Basic calcium phosphate (BCP) is a chemical compound that occurs naturally in the body. This compound can form crystals that cause joint pain and swelling similar to those of gout (including podagra), calcium pyrophosphate arthritis (previously and sometimes still called pseudogout), or sometimes other joint disorders. Basic calcium phosphate crystals can also form in tendons and connective tissues.

Milwaukee shoulder/knee syndrome is 1 example of basic calcium phosphate crystal deposition disease. It is a destructive disorder that mostly affects the shoulders and often the knees, with marked and persistent joint swelling, in older women.

Acute pseudopodagra is another joint disorder caused by basic calcium phosphate crystals and can mimic gout. It affects the joints of the big toe and occurs in young women (less often young men).

Dalili za Ugonjwa wa Kukusanyika kwa Fuwele za BCP

Basic calcium phosphate crystals cause pain and severe inflammation in and around joints. The crystals occasionally destroy the joints.

Utambuzi wa Ugonjwa wa Kukusanyika kwa Fuwele za BCP

  • X-rays

  • Microscopic examination of joint fluid

To check for basic calcium phosphate crystals, doctors take x-rays. These crystals are sometimes visible on x-rays around the joints, and not usually in the joint cartilage.

Doctors may also need to use a needle to withdraw joint fluid (joint aspiration) and test it for crystals. Basic calcium phosphate crystals are small and usually can be seen only with a special stain or a transmission electron microscope.

Matibabu ya Ugonjwa wa Kukusanyika kwa Fuwele za BCP

  • Nonsteroidal anti-inflammatory drugs

  • Colchicine taken by mouth

  • A steroid injection into the joint

Basic calcium phosphate deposition disorder is usually treated similarly to gout, with nonsteroidal anti-inflammatory drugs (NSAIDs), colchicine taken by mouth, or a steroid injection into the joint (see table Drugs Used to Treat Gout).

There is no way to completely rid the body of these crystals.