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Medication Class	Indications
ACE inhibitors*	Youth Left ventricular failure due to systolic dysfunction† Diabetes with nephropathy Albumin:creatinine ratio > 30 mg/gram (> 33.9 mg/mmol) in patients with chronic renal disorders or diabetic glomerulosclerosis Erectile dysfunction due to other medications
Angiotensin II receptor blockers*	Youth Conditions for which ACE inhibitors are indicated but not tolerated because of cough or angioedema Diabetes with nephropathy Left ventricular failure with systolic dysfunction Secondary stroke
Long-acting calcium channel blockers	Older age Angina pectoris Arrhythmias (eg, atrial fibrillation, paroxysmal supraventricular tachycardia) Isolated systolic hypertension in older patients (dihydropyridines)† High CAD risk (nondihydropyridines)†
Thiazide-type diuretics† (chlorthalidone or indapamide)Thiazide-type diuretics† (chlorthalidone or indapamide)	Older age Heart failure
* Contraindicated in pregnancy.
† Reduced morbidity and mortality rates in randomized studies.
ACE = angiotensin-converting enzyme; CAD = coronary artery disease.