A catheter-associated urinary tract infection (CAUTI) is a urinary tract infection (UTI) in which the positive culture was taken when an indwelling urinary catheter had been in place for > 2 consecutive days while the catheter is in place or within 1 day after it is removed. Patients with indwelling bladder catheters are predisposed to bacteriuria and UTIs. Symptoms may be vague or may suggest sepsis. Diagnosis depends on the presence of symptoms. Testing includes urinalysis and culture after the catheter has been removed and a new one has been inserted. The most effective preventive measures are avoiding unnecessary catheterization and removing catheters as soon as possible.
(See also Introduction to Urinary Tract Infections [UTIs].)
Bacteria can enter the bladder during insertion of the catheter, through the catheter lumen, or from around the outside of the catheter. A biofilm develops around the outside of the catheter and on the uroepithelium. Bacteria enter this biofilm, which protects them from the mechanical flow of urine, host defenses, and antibiotics, making bacterial elimination difficult. Even with thoroughly aseptic catheter insertion and care, the chance of developing significant bacteriuria is about 5% every day the catheter is indwelling (1). Of patients who develop bacteriuria, up to 24% develop a UTI with symptoms (2, 3). Fewer develop sepsis.
Risk factors for UTI include duration of catheterization, female sex, diabetes mellitus, opening a closed system, and suboptimal aseptic techniques. Indwelling bladder catheters can also predispose to fungal UTI (4, 5).
UTIs can also develop in women during the days after a catheter has been removed.
General references
1. Warren JW, Platt R, Thomas RJ, et al. Antibiotic irrigation and catheter-associated urinary-tract infections. N Engl J Med. 1978;299(11):570-573. doi:10.1056/NEJM197809142991103
2. Saint S. Clinical and economic consequences of nosocomial catheter-related bacteriuria. Am J Infect Control. 2000;28(1):68-75. doi:10.1016/s0196-6553(00)90015-4
3. Leuck AM, Wright D, Ellingson L, et al. Complications of Foley catheters--Is infection the greatest risk? J Urol. 2012;187(5):1662-1666. doi:10.1016/j.juro.2011.12.113
4. Letica-Kriegel AS, Salmasian H, Vawdrey DK, et al. Identifying the risk factors for catheter-associated urinary tract infections: a large cross-sectional study of six hospitals. BMJ Open. 2019;9(2):e022137. Published 2019 Feb 21. doi:10.1136/bmjopen-2018-022137
5. Patel PK, Advani SD, Kofman AD, et al. Strategies to prevent catheter-associated urinary tract infections in acute-care hospitals: 2022 Update. Infect Control Hosp Epidemiol. 2023;44(8):1209-1231. doi:10.1017/ice.2023.137
Symptoms and Signs of Catheter-Associated UTIs
Patients with catheter-associated urinary tract infection (CAUTI) may not have some of the symptoms typical of UTIs (eg, dysuria, frequency), but they may feel the need to urinate or have suprapubic discomfort. However, such symptoms of lower tract UTI may also be caused by obstruction of the catheter or development of bladder calculi. Symptoms of acute or chronic pyelonephritis may also develop without the typical urinary tract symptoms. Patients may have nonspecific symptoms such as malaise, fever, flank pain, anorexia, altered mental status, and signs of sepsis.
Diagnosis of Catheter-Associated UTIs
Urinalysis and urine culture for patients with symptoms or at high risk of sepsis
Testing should be performed only in patients who might require treatment, including those who have symptoms and those at high risk of developing sepsis, such as:
Patients with granulocytopenia
Patients who have an organ transplant and are taking immunosuppressants
Pregnant patients
Patients undergoing urologic surgery
Diagnostic testing includes urinalysis and urine culture. If bacteremia is suspected, blood cultures are performed. Urine cultures should be obtained, preferably after replacing the catheter (to avoid culturing colonizing bacteria), then by a direct needlestick of the catheter, all done with aseptic technique, so that contamination of the specimen is minimized.
Treatment of Catheter-Associated UTIs
Antibiotics
Asymptomatic, low-risk patients are not treated. Symptomatic and high-risk patients are treated with antibiotics and supportive measures. The catheter should be replaced when treatment begins. Choice of empiric antibiotic is as for acute pyelonephritis. Subsequently, antibiotics with the narrowest spectrum of activity, based on culture and sensitivity testing, should be used. Optimal duration is not well established, but 7 to 14 days is reasonable in patients who had a satisfactory clinical response, including resolution of systemic manifestations.
Prevention of Catheter-Associated UTIs
The most effective preventive measures are avoiding catheterization and removing catheters as soon as possible (1). Optimizing aseptic technique and maintaining a closed drainage system also reduce risk. The optimal frequency and even whether to routinely change indwelling catheters is unknown. Intermittent catheterization carries less risk than use of an indwelling catheter and should be used instead whenever feasible. Antibiotic prophylaxis and antibiotic-coated catheters are not recommended for patients who require long-term indwelling catheters.
UTIs are one of the most common types of health care-associated infection (2).
Prevention references
1. Patel PK, Advani SD, Kofman AD, et al. Strategies to prevent catheter-associated urinary tract infections in acute-care hospitals: 2022 Update. Infect Control Hosp Epidemiol. 2023;44(8):1209-1231. doi:10.1017/ice.2023.137
2. Centers for Disease Control and Prevention. Clinical Safety: Preventing Catheter-associated Urinary Tract Infections (CAUTIs). June 27, 2025. Accessed November 6, 2025.
Key Points
Long-term use of indwelling bladder catheters increases risk of bacteriuria, and bacteriuria is usually asymptomatic.
Symptomatic UTI may manifest with systemic symptoms (eg, fever, altered mental status, decreased blood pressure) and with few or no symptoms typical of UTIs.
Perform urinalysis and urine culture if patients have symptoms or are at high risk of sepsis (eg, because of immunocompromise).
Treat similarly to other complicated UTIs.
Whenever possible, avoid use of catheters or remove them at the first opportunity.
