Hypohidrosis due to skin abnormalities is rarely clinically significant. It is most commonly focal and caused by local skin injury (eg, due to trauma, radiation, infection [eg, leprosy], or inflammation) or by atrophy of glands resulting from connective tissue disease (eg, systemic sclerosis, systemic lupus erythematosus, Sjögren syndrome).
Hypohidrosis may be caused by drugs, especially those with anticholinergic properties. It is also caused by diabetic neuropathy and a variety of congenital syndromes. Heatstroke causes inadequate sweating but is a central nervous system disorder rather than a skin disorder.
Diagnosis of hypohidrosis is by clinical observation of decreased sweating or by heat intolerance.
Treatment of hypohidrosis is by cooling measures (eg, air-conditioning, wet garments).
(See also Introduction to Sweating Disorders.)