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Overview of the Digestive System

By

Michael Bartel

, MD, PhD, Fox Chase Cancer Center, Temple University

Medically Reviewed Oct 2022
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The digestive system, which extends from the mouth to the anus, is responsible for receiving food, breaking it down into nutrients (a process called digestion), absorbing the nutrients into the bloodstream, and eliminating the indigestible parts of food from the body. The digestive tract consists of the

The digestive system also includes organs that lie outside the digestive tract:

The digestive system is sometimes called the gastrointestinal system, but neither name fully describes the system’s functions or components. The organs of the digestive system also produce blood clotting factors and hormones unrelated to digestion, help remove toxic substances from the blood, and chemically alter (metabolize) drugs.

The abdominal cavity is the space that holds most of the digestive organs. It is bordered by the abdominal wall (composed of layers of skin, fat, muscle, and connective tissue) in front, the spinal column in back, the diaphragm above, and the pelvic organs below. It is lined by a membrane called the peritoneum. The peritoneum lines most of the outer surfaces of the digestive organs.

Experts have recognized a powerful connection between the digestive system and the brain. For example, psychologic factors greatly influence contractions of the intestine, secretion of digestive enzymes, and other functions of the digestive system. Even susceptibility to infection, which leads to various digestive system disorders, is strongly influenced by the brain. In turn, the digestive system influences the brain. For example, long-standing or recurring diseases such as irritable bowel syndrome Irritable Bowel Syndrome (IBS) Irritable bowel syndrome is a disorder of the digestive tract that causes recurring abdominal pain and constipation or diarrhea. Symptoms vary but often include lower abdominal pain, bloating... read more , ulcerative colitis Ulcerative Colitis Ulcerative colitis is a chronic inflammatory bowel disease in which the large intestine (colon) becomes inflamed and ulcerated (pitted or eroded), leading to flare-ups (bouts or attacks) of... read more , and other painful diseases affect emotions, behaviors, and daily functioning. This two-way association has been called the brain-gut axis.

The Digestive System

The Digestive System
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