Rifamycins are antibiotics that work by suppressing the bacteria's production of genetic material. As a result, the bacteria die.
Rifamycins include the following:
Rifampin, rifabutin, and rifapentine are used in combination with other antibiotics to treat tuberculosis and infections related to tuberculosis. They have similar side effects.
Rifampin is often used in combination with other antibiotics to treat leprosy and artificial valves and joints infected with staphylococci.
Rifaximin is used to treat traveler's diarrhea caused by Escherichia coli (E. coli).
Rifamycins
Drugs | Common Uses | Some Potential Side Effects |
|---|---|---|
Rash Liver dysfunction Gastrointestinal upset Red-orange discoloration of saliva, sweat, tears, and urine and of soft contact lenses Interactions with many drugs, often requiring changes in the dose | ||
Nausea, vomiting, abdominal pain, and flatulence |
(See also Overview of Antibiotics.)
Use of Rifamycins During Pregnancy and Breastfeeding
Rifamycins are used during pregnancy only when the benefits of treatment outweigh the risks. With rifabutin, some harmful effects on the fetus have been observed in animal studies. With rifampin and rifapentine, harmful effects on the fetus (including birth defects) have been observed in animal studies. (See also Drug Use During Pregnancy.)
Use of rifamycins during breastfeeding is not recommended, but the decision to stop breastfeeding or to stop rifampin should be made depending on the importance of the drug to the mother's health. (See also Drug Use During Breastfeeding.)
