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Rifamycins

By

Brian J. Werth

, PharmD, University of Washington School of Pharmacy

Last full review/revision Jul 2020| Content last modified Jul 2020
CLICK HERE FOR THE PROFESSONAL VERSION
Topic Resources

Rifamycins include the following:

  • Rifabutin

  • Rifampin

  • Rifapentine

  • Rifaximin

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Use of Rifamycins During Pregnancy and Breastfeeding

Rifamycins are used during pregnancy only when the benefits of treatment outweigh the risks. With rifabutin, no harmful effects on the fetus have been observed in animal studies, but no well-designed studies have been done in pregnant women. With rifampin and rifapentine, harmful effects on the fetus (including birth defects) have been observed in animal studies. (See also Drug Use During Pregnancy Drug Use During Pregnancy More than 50% of pregnant women take prescription or nonprescription (over-the-counter) drugs or use social drugs (such as tobacco and alcohol) or illicit drugs at some time during pregnancy... read more .)

Use of rifamycins during breastfeeding is not recommended. A decision to stop breastfeeding or to stop rifampin should be made depending on the importance of the drug to the mother's health. (See also Drug Use During Breastfeeding Drug Use During Breastfeeding When mothers who are breastfeeding have to take a drug, they wonder whether they should stop breastfeeding. The answer depends on the following: How much of the drug passes into the milk Whether... read more .)

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