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Oral Growths


Bernard J. Hennessy

, DDS, Texas A&M University, College of Dentistry

Last full review/revision May 2020
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Topic Resources

Growths can originate in any type of tissue in and around the mouth, including connective tissues, bone, muscle, and nerve. Most commonly, growths form on the lips, the sides of the tongue, the floor of the mouth, and the soft palate. Some growths cause pain or irritation. Growths may be noticed by the patient or discovered only during routine examination.

Etiology of Oral Growths

Oral growths can be

  • Benign

  • Premalignant (dysplastic)

  • Malignant

Benign oral growths

Most oral growths are benign; there are numerous types.

Oral Growths

Chronic irritation can cause a persistent lump or raised area on the gingiva. Benign growths due to irritation are relatively common and, if necessary, can be removed by surgery. In 10 to 40% of people, benign growths on the gingiva reappear because the irritant remains. Occasionally such irritation, particularly if it persists over a long period of time, can lead to premalignant or malignant changes.

Oral candidiasis Candidiasis (Mucocutaneous) Candidiasis is skin and mucous membrane infection with Candida species, most commonly Candida albicans. Infections can occur anywhere and are most common in skinfolds, digital web spaces, genitals... read more Candidiasis (Mucocutaneous) (thrush) often appears as white, cheesy plaques that stick tightly to the mucous membranes and leave red erosions when wiped off. Thrush is most common among patients with diabetes or immunocompromise and among those who are taking antibiotics.

Cysts of many kinds cause jaw pain and swelling. Often they are associated with an impacted wisdom tooth and can destroy considerable areas of the mandible as they expand. Certain types of cysts are more likely to recur after surgical removal. Various types of cysts may also develop in the floor of the mouth. Often, these cysts are surgically removed because they make swallowing uncomfortable or because they are unattractive.

Mucoceles (mucus retention cysts) and ranulas are painless, benign, intraoral swellings due to cystic or pseudocystic accumulations of salivary gland mucus. They are often traumatic in origin. By far the most common lesion, mucoceles most often occur inside the lateral lower lip and often have a bluish translucent color due to presence of spilled mucin under the mucosa. They are usually the result of accidentally biting the (lower) lip and occur when salivary flow from a minor salivary gland is obstructed. Most mucoceles disappear in a week or two. Ranulas are large, usually bluish mucoceles on the floor of the mouth. Treatment is surgical excision.

A torus is a rounded projection of bone that forms in the midline of the hard palate (torus palatinus) or on the inner aspect of the mandible (torus mandibularis). This hard growth is both common and harmless. Even a large growth can be left alone unless it gets traumatized during eating or the person needs a denture that covers the area.

Gardner syndrome is a type of familial adenomatous polyposis Familial Adenomatous Polyposis Familial adenomatous polyposis is a hereditary disorder causing numerous colonic polyps and frequently resulting in colon carcinoma, often by age 40. Patients are usually asymptomatic but may... read more Familial Adenomatous Polyposis , a hereditary disorder of the gastrointestinal tract that involves multiple colorectal polyps. Patients who have Gardner syndrome often present with multiple oral osteomas that may clinically resemble multiple torus lesions, particularly in the body and angle of the lower jaw.

Keratoacanthomas Keratoacanthoma Keratoacanthomas are round, firm, usually flesh-colored nodules with sharply sloping borders and a characteristic central crater containing keratinous material; they usually resolve spontaneously... read more Keratoacanthoma are growths that form on the lips and other sun-exposed areas, such as the face, forearms, and hands. A keratoacanthoma usually reaches its full size of about 1 to 3 cm or more in diameter within 1 or 2 months, then begins to shrink after another few months and may eventually disappear without treatment. Once, all keratoacanthomas were considered to be noncancerous, but some experts now consider those that do not diminish in size to be low-grade cancerous lesions, and biopsy or excision is currently recommended for such lesions.

Odontomas are overgrowths of tooth-forming cells that look like small, misshapen extra teeth. In children, they may get in the way of normal tooth eruption. In adults, they may push teeth out of alignment. Large odontomas may also cause enlargement of the maxilla or mandible. They are usually removed surgically.

Salivary gland tumors Salivary Gland Tumors Most salivary gland tumors are benign and occur in the parotid glands. A painless salivary mass is the most common sign and is evaluated by fine-needle aspiration biopsy. Imaging with CT and... read more Salivary Gland Tumors are mostly (75 to 80%) benign, slow-growing, and painless. They usually occur as a single, soft, movable lump beneath normal-appearing skin or under the oral mucosa. Occasionally, when hollow and fluid-filled, they are firm. The most common type is a pleomorphic adenoma (mixed tumor) and it occurs mainly in women > age 40. Pleomorphic adenomas can become malignant and are removed surgically. Unless completely removed, this type of tumor is likely to recur. Other types of benign tumors are also removed surgically but are much less likely to become malignant or recur.

Premalignant (dysplastic) changes

White, red, or mixed white-red areas that are not easily wiped away, persist for > 2 weeks, and are not definable as some other condition may be dysplastic. The same risk factors are involved in dysplastic changes as in malignant growths, and dysplastic changes may become malignant if not removed.

Leukoplakia is a flat white spot that may develop when the oral mucosa is irritated for a long period. The irritated spot appears white because it has a thickened layer of keratin, which normally is less abundant in the oral mucosa. Factors often associated with the development of idiopathic oral leukoplakia include tobacco use, alcohol consumption, vitamin deficiency, and endocrine disturbances.

Erythroplakia is a red and flat or worn-away area that results when the oral mucosa thins. The area appears red because the underlying capillaries are more visible. Erythroplakia is a much more ominous predictor of oral cancer than leukoplakia.

Mixed lesions show intermixed areas of leukoplakia and erythroplakia and also may be precursors of cancer.

Oral cancer

People who use tobacco, alcohol, or both are at much greater risk (up to 15 times) of oral cancer Oral Squamous Cell Carcinoma Oral cancer refers to cancer occurring between the vermilion border of the lips and the junction of the hard and soft palates or the posterior one third of the tongue. Over 95% of people with... read more Oral Squamous Cell Carcinoma . For people who use chewing tobacco and snuff, the insides of the cheeks and lips are common sites. In other people, the most common sites for cancer include the lateral borders of the tongue, the floor of the mouth, and the oropharynx. Human papillomavirus (HPV) infection Human Papillomavirus (HPV) Infection Human papillomavirus (HPV) causes warts. Some types cause skin warts, and other types cause raised or flat genital warts (lesions of the skin or mucous membranes of the genitals). Infection... read more Human Papillomavirus (HPV) Infection , especially type 16, is a risk factor for oral cancer, primarily in the tonsils and at the base of the tongue; at these sites, HPV16 has surpassed tobacco as the primary cause. Rarely, cancers found in the oral region have metastasized from the lungs, breast, or prostate.

Oral cancer can have many different appearances but typically resembles dysplastic lesions (eg, white, red, or mixed white-red areas that are not easily wiped away).

Evaluation of Oral Growths


History of present illness includes questions about how long the growth has been present, whether it is painful, and whether there has been any injury to the area (eg, biting a cheek, scraping by a sharp tooth edge or dental restoration). Patients are asked about symptoms of systemic illness, particularly weight loss and malaise.

Physical examination

The physical examination focuses on the mouth and neck, inspecting and palpating all areas of the mouth and throat, including under the tongue. The neck is palpated for lymphadenopathy, which suggests possible cancer or chronic infection.

Red flags

The following findings are of particular concern:

  • Weight loss

  • Neck mass

  • Persistent sore throat

  • Difficulty swallowing

Interpretation of findings

The main concern is to not mistake an oral cancer or dysplastic lesion for a benign disorder. Clinicians should maintain a high degree of suspicion and refer the patient for biopsy if the lesion does not resolve in a few weeks.


Suspected candidiasis Candidiasis (Mucocutaneous) Candidiasis is skin and mucous membrane infection with Candida species, most commonly Candida albicans. Infections can occur anywhere and are most common in skinfolds, digital web spaces, genitals... read more Candidiasis (Mucocutaneous) can be confirmed by finding yeast and pseudohyphae in 10% potassium hydroxide wet mounts of scrapings from a lesion. Other acute lesions, particularly those that appear related to local trauma or irritation, may be observed. However, most lesions present for more than a few weeks, and those of unknown duration should be biopsied because cancer is difficult to exclude clinically.

Treatment of Oral Growths

  • Dependent on cause

Treatment depends on the cause of the growth.

Key Points

  • Most oral growths are benign.

  • Warts, candidal infections, and repeated trauma are common causes of benign growths.

  • Use of alcohol and tobacco is a risk factor for cancer.

  • Because cancer is difficult to diagnose by inspection, biopsy is often necessary.

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