Hypohidrosis is inadequate sweating.
Hypohidrosis due to skin abnormalities is rarely clinically significant. It is most commonly focal and caused by local skin injury (eg, due to trauma, radiation, infection [eg, leprosy], or inflammation) or by atrophy of glands resulting from connective tissue disease (eg, systemic sclerosis, systemic lupus erythematosus, Sjögren syndrome).
Hypohidrosis is a feature of some genetic conditions (eg, hypohidrotic and anhidrotic ectodermal dysplasia). A mutation of a single gene (ITPR2), which encodes a calcium channel, results in anhidrosis, the complete absence of sweating (1).
Hypohidrosis may be caused by drugs, especially those with anticholinergic properties. It is also caused by diabetic neuropathy and a variety of congenital syndromes. Heatstroke causes inadequate sweating but is a central nervous system disorder rather than a skin disorder.
Diagnosis of hypohidrosis is by clinical observation of decreased sweating or by heat intolerance.
Treatment of hypohidrosis is by cooling measures (eg, air-conditioning, wet garments).
(See also Introduction to Sweating Disorders.)
Джерела літератури
1. Klar J, Hisatsune C, Baig SM, Tariq M, et al: Abolished InsP3R2 function inhibits sweat secretion in both humans and mice. J Clin Invest 124(11):4773–4780, 2014. doi: 10.1172/JCI70720