[{"Title":"Загальний довідковий матеріал щодо лікарських засобів","UniqueID":"v96550437_uk","Index":1.0,"Summary":"

1. Whelton PK, Carey RM, Aronow WS, et al: 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension 71(6):e13–e115, 2018. doi: 10.1161/HYP.0000000000000065

","HeadType":"G_Head","SchemeItemProp":"","Children":[]},{"Title":"Діуретики","UniqueID":"v84063861_uk","Index":2.0,"Summary":"

Main classes of diuretics used for hypertension (see table Oral Diuretics for Hypertension) are

","HeadType":"F_Head","SchemeItemProp":"","Children":[{"Title":"Довідкові матеріали щодо діуретиків","UniqueID":"v84063900_uk","Index":1.0,"Summary":"

Main classes of diuretics used for hypertension (see table Oral Diuretics for Hypertension) are

","HeadType":"G_Head","SchemeItemProp":"","Children":[]}]},{"Title":"Інгібітори ангіотензинперетворюючого ферменту (АПФ)","UniqueID":"v84063713_uk","Index":3.0,"Summary":"

ACE inhibitors (see table Oral ACE Inhibitors and Angiotensin II Receptor Blockers for Hypertension) reduce blood pressure by interfering with the conversion of angiotensin I to angiotensin II and by inhibiting the degradation of bradykinin, thereby decreasing peripheral vascular resistance without causing reflex tachycardia. These medications reduce BP in many patients with hypertension, regardless of plasma renin activity. Because these medications provide renal protection, they (along with angiotensin II receptor blockers) are the medications of choice for patients with diabetes . They are not recommended for initial treatment in patients with African ancestry, in whom they appear to increase the risk of stroke when used for initial treatment.

","HeadType":"F_Head","SchemeItemProp":"","Children":[{"Title":"Довідкові матеріали щодо інгібіторів АПФ","UniqueID":"v84063734_uk","Index":1.0,"Summary":"

","HeadType":"G_Head","SchemeItemProp":"","Children":[]}]},{"Title":"Блокатори рецепторів ангіотензину II (БРА)","UniqueID":"v84063749_uk","Index":4.0,"Summary":"

Angiotensin II receptor blockers (see table Oral ACE Inhibitors and Angiotensin II Receptor Blockers for Hypertension) block angiotensin II receptors and therefore interfere with the renin-angiotensin system . Angiotensin II receptor blockers and ACE inhibitors are equally effective as antihypertensives. Angiotensin II receptor blockers may provide added benefits via tissue ACE blockade. The 2 classes have the same beneficial effects in patients with left ventricular failure or with nephropathy due to type 1 diabetes . An angiotensin II receptor blocker should not be used together with an ACE inhibitor, but when used with a beta-blocker may reduce the hospitalization rate for patients with heart failure. Angiotensin II receptor blockers may be safely used in anyone with an estimated GFR > 30 mL/minute to reduce cardiovascular risk and kidney disease progression.

","HeadType":"F_Head","SchemeItemProp":"","Children":[]},{"Title":"Блокатори кальцієвих каналів","UniqueID":"v84063801_uk","Index":5.0,"Summary":"

Dihydropyridines (see table Oral Calcium Channel Blockers for Hypertension) are potent peripheral vasodilators and reduce blood pressure by decreasing total peripheral vascular resistance (TPR); they sometimes cause reflexive tachycardia.

","HeadType":"F_Head","SchemeItemProp":"","Children":[{"Title":"Довідкові матеріали щодо блокаторів кальцієвих каналів","UniqueID":"v84063816_uk","Index":1.0,"Summary":"

","HeadType":"G_Head","SchemeItemProp":"","Children":[]}]},{"Title":"Інгібітор реніну","UniqueID":"v84063823_uk","Index":6.0,"Summary":"

Aliskiren, a direct renin inhibitor, is used in the management of hypertension.

","HeadType":"F_Head","SchemeItemProp":"","Children":[]},{"Title":"Бета-блокатори","UniqueID":"v84063769_uk","Index":7.0,"Summary":"

Beta-blockers are not first line agents for treatment of hypertension. However, they may be useful in patients with hypertension who have other disorders that may benefit from a beta-blocker, such as angina , previous myocardial infarction , or heart failure . Otherwise, beta-blockers are less protective against stroke and overall mortality than some other antihypertensives ( 1 , 2 ).

","HeadType":"F_Head","SchemeItemProp":"","Children":[{"Title":"Довідкові матеріали щодо бета-блокаторів","UniqueID":"v84063789_uk","Index":1.0,"Summary":"

","HeadType":"G_Head","SchemeItemProp":"","Children":[]}]},{"Title":"Модифікатори альфа-адренергічних рецепторів","UniqueID":"v84063703_uk","Index":8.0,"Summary":"

Adrenergic modifiers include central alpha-2-agonists, postsynaptic alpha-1-blockers, and peripheral-acting non-selective adrenergic blockers (see table Adrenergic Modifiers for Hypertension).

","HeadType":"F_Head","SchemeItemProp":"","Children":[]},{"Title":"Судинорозширювальні препарати прямої дії","UniqueID":"v84063834_uk","Index":9.0,"Summary":"

Direct vasodilators, including minoxidil and hydralazine (see table Direct Vasodilators for Hypertension), work directly on blood vessels, independently of the autonomic nervous system. Minoxidil is more potent than hydralazine but has more adverse effects, including sodium and water retention and hypertrichosis, which may be poorly tolerated. Minoxidil should be reserved for severe, refractory hypertension.

","HeadType":"F_Head","SchemeItemProp":"","Children":[{"Title":"Довідкові матеріали щодо судинорозширювальних препаратів прямої дії","UniqueID":"v84063848_uk","Index":1.0,"Summary":"

","HeadType":"G_Head","SchemeItemProp":"","Children":[]}]}]