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Some Medications and Toxins That Can Cause Jaundice

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Mechanism	Medications or Toxins
Increased bilirubin production	Medications that cause hemolysis (common among patients with glucose-6-phosphate dehydrogenase [G6PD] deficiency), such as sulfa drugs and nitrofurantoin), such as sulfa drugs and nitrofurantoin
Decreased hepatic uptake	Chloramphenicol, probenecid, rifampinChloramphenicol, probenecid, rifampin
Decreased conjugation	Ethinyl estradiol
Hepatocellular dysfunction	Acetaminophen (high dose or overdose), amiodarone, isoniazid, , amiodarone, isoniazid,nonsteroidal anti-inflammatory drugs, statins, many others, many medication combinations Amanita phalloides mushrooms, carbon tetrachloride, phosphorus (see Hydrocarbon Poisoning and Volatile Solvents)
Intrahepatic cholestasis	Amoxicillin/clavulanate, anabolic steroids, chlorpromazine, pyrrolizidine alkaloids (eg, in , chlorpromazine, pyrrolizidine alkaloids (eg, inherbal preparations), oral contraceptives, phenothiazines