Causes of ArginineVasopressin Deficiency

Decreased synthesis of vasopressin

Decreased synthesis of vasopressin

Primary argininevasopressin deficiency, hereditary (usually autosomal dominant)

Acquired (secondary) argininevasopressin deficiency (causes outlined in text)

Wolfram syndrome (primary argininevasopressin deficiency, diabetes mellitus, optic nerve atrophy, nerve deafness, and atonia of bladder and ureters (autosomal recessive)

Decreased release of vasopressin

Primary polydipsia

Vasopressin-resistant polyuria

Secretion of vasopressinase during the latter half of pregnancy (rare)

Gestational diabetes insipidus

Secretion of an ineffective ADH antagonist rather than vasopressin (rare)

Hypothalamic surgery