Mupirocin

Mupirocin inhibits bacterial RNA and protein synthesis. It is available only as a 2% topical preparation, which is bactericidal against staphylococci and beta-hemolytic streptococci. Systemic absorption of topical mupirocin is negligible.

Mupirocin is used for

• Impetigo

• Minor superficial secondarily infected skin lesions

• Eradication of Staphylococcus aureus nasal carriage, although relapse rates may be high

Chronic therapy leads to mupirocin-resistant staphylococci.

Mupirocin is nontoxic but, when applied to denuded skin or mucous membranes, may cause itching and burning.