Overview of Arteriosclerosis

ByAttila Feher, MD, PhD, Yale University School of Medicine
Reviewed ByJonathan G. Howlett, MD, Cumming School of Medicine, University of Calgary
Reviewed/Revised Modified Oct 2025
v103687415
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Arteriosclerosis is a general term that refers to the hardening and thickening of the walls of the arteries. It is a condition in which the arteries become stiff, less elastic, and thickened.

There are 2 major types of arteriosclerosis:

  1. Atherosclerosis, which involves development of lipid rich deposits (atheromas) inside the arterial walls

  2. Nonatheromatous arteriosclerosis

Atherosclerosis is the most common form of arteriosclerosis, a general term for several disorders that cause thickening and loss of elasticity in the arterial wall. Atherosclerosis is also the most serious and clinically relevant form of arteriosclerosis because it underlies coronary artery disease, cerebrovascular disease, and peripheral artery disease.

Nonatheromatous forms of arteriosclerosis include:

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