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Kidney Cancer

(Adenocarcinoma of the Kidney; Renal Cell Carcinoma)

By

J. Ryan Mark

, MD, Sidney Kimmel Cancer Center at Thomas Jefferson University

Last full review/revision Aug 2019| Content last modified Aug 2019
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Topic Resources
  • Kidney cancer may cause blood in the urine, pain in the side, or fever.

  • Cancer is most often detected by accident when an imaging test is done for another reason.

  • Diagnosis is by computed tomography or magnetic resonance imaging.

  • Removing the kidney prolongs survival and may be curative if cancer has not spread.

Kidney cancer accounts for about 2 to 3% of cancers in adults, affecting about 50% more men than women. About 73,820 people develop kidney cancer each year and about 14,770 die of it (2019 estimates). Smokers are about twice as likely to develop kidney cancer as nonsmokers. Other risk factors include exposure to toxic chemicals (for example, asbestos, cadmium, leather tanning, and petroleum products) and obesity. People who are undergoing dialysis Dialysis Dialysis is an artificial process for removing waste products and excess fluids from the body, a process that is needed when the kidneys are not functioning properly. There are a number of reasons... read more Dialysis and develop cystic kidney disease Cystic Kidney Disorders read more and people with certain inherited disorders are also at higher risk of kidney cancer. People affected are usually between 50 and 70 years of age.

Most solid kidney tumors are cancerous, but purely fluid-filled tumors (cysts) generally are not. Almost all kidney cancer is renal cell carcinoma. Another kind of kidney cancer, Wilms tumor Wilms Tumor Wilms tumor is a specific kind of kidney cancer that occurs mainly in young children. The cause of Wilms tumor is not known, but some children may have a genetic abnormality that increases their... read more , occurs more often in children.

Symptoms of Kidney Cancer

Symptoms may not occur until the cancer has spread (metastasized) or become very large. Blood in the urine is the most common first symptom, but the amount of blood may be so small that it can be detected only under a microscope. On the other hand, the urine may be visibly red. The next most common symptoms are pain in the area between the ribs and hip (the flank), fever, and weight loss. Infrequently, a kidney cancer is first detected when a doctor feels an enlargement or lump in the abdomen.

The red blood cell count may become abnormally high (polycythemia) because high levels of the hormone erythropoietin (which is produced by the diseased kidney or by the tumor itself) stimulate the bone marrow to increase the production of red blood cells. Symptoms of a high red blood cell count may be absent or may include headache, fatigue, dizziness, and vision disturbances. Conversely, kidney cancer may lead to a drop in the red blood cell count (anemia Overview of Anemia Anemia is a condition in which the number of red blood cells is low. Red blood cells contain hemoglobin, a protein that enables them to carry oxygen from the lungs and deliver it to all parts... read more ) because of slow bleeding into the urine. Anemia may cause easy fatigability or dizziness. Some people develop high levels of calcium in the blood (hypercalcemia Hypercalcemia (High Level of Calcium in the Blood) In hypercalcemia, the level of calcium in blood is too high. A high calcium level may result from a problem with the parathyroid glands, as well as from diet, cancer, or disorders affecting... read more Hypercalcemia (High Level of Calcium in the Blood) ), which may cause weakness, fatigue, slowed reaction times, and constipation. Blood pressure may increase, but high blood pressure may not cause symptoms.

Diagnosis of Kidney Cancer

  • Computed tomography or magnetic resonance imaging

  • Sometimes surgery

If cancer is diagnosed, other imaging tests (for example, chest x-ray, bone scan, or CT of the head, chest, or both) as well as blood tests may be done to determine whether and where the cancer has spread. However, sometimes cancer that has recently spread cannot be detected. Occasionally, surgery is needed to confirm the diagnosis.

Prognosis of Kidney Cancer

Treatment of Kidney Cancer

  • Surgery

When the cancer has not spread beyond the kidney, surgically removing the affected kidney provides a reasonable chance of cure. Alternatively, surgeons may remove only the tumor with a rim of adjacent normal tissue, which spares the remainder of the kidney. Although some nonsurgical means of destroying cancer cells are being studied, surgery is usually preferred.

If the cancer has spread into adjacent sites such as the renal vein or even the large vein that carries blood to the heart (vena cava) but has not spread to lymph nodes or distant sites, surgery may still provide a chance for cure. However, kidney cancer has a tendency to spread early, especially to the lungs, sometimes before symptoms develop. Because kidney cancer that has spread to distant sites may escape early diagnosis, metastasis sometimes becomes apparent only after doctors have surgically removed all of the kidney cancer that could be found.

If surgical cure seems unlikely, other treatments can be used, although cure rarely results. Treating the cancer by enhancing the immune system’s ability to destroy it causes some cancers to shrink and may prolong survival (see Immunotherapy Immunotherapy for Cancer Immunotherapy is used to stimulate the body's immune system against cancer. These treatments target specific genetic characteristics of the tumor cells. The genetic characteristics of tumors... read more ). Such treatments sometimes used for kidney cancer include interleukin-2 and interferon alfa-2b. Other drugs sometimes used include sunitinib, sorafenib, cabozantinib, axitinib, bevacizumab, pazopanib, lenvatinib, temsirolimus, and everolimus. These drugs alter molecular pathways that affect the tumor and are thus called targeted therapies.

New immunotherapies called checkpoint inhibitors block a molecule on cancer cells called PD-L1 from binding to PD-1 on T-cells allowing the immune system to attack the cancer. Pembrolizumab + axitinib and nivolumab + ipilimumab pembrolizumab are approved checkpoint inhibitors for first-line use in good and intermediate/poor risk patients with metastatic disease. Other combinations of therapies including checkpoint inhibitors are currently a topic of investigation.

Various combinations of other interleukins, thalidomide, and even vaccines developed from cells removed from the kidney cancer are also being investigated. These treatments may be helpful for metastatic cancer, although the benefit is usually small. Rarely (in less than 1% of people), removing the affected kidney causes tumors elsewhere in the body to shrink. However, the slim possibility that tumor shrinkage will occur is not considered sufficient reason to remove a cancerous kidney when the cancer has already spread, unless removal is part of an overall plan that includes other treatments directed toward widespread cancer. In 2017 sunitinib was approved as a way to help prevent kidney cancer from returning after surgery.

Tumors Metastatic to the Kidney

Sometimes cancers in other areas of the body spread (metastasize) to the kidneys. Examples of such cancers include melanoma Melanoma Melanoma is a skin cancer that begins in the pigment-producing cells of the skin (melanocytes). Melanomas can begin on normal skin or in existing moles. They may be irregular, flat or raised... read more Melanoma ; cancers of the lung Lung Cancer Lung cancer is the leading cause of cancer death in both men and women. About 85% of cases are related to cigarette smoking. One common symptom is a persistent cough or a change in the character... read more Lung Cancer , breast Breast Cancer Breast cancer occurs when cells in the breast become abnormal and divide uncontrollably. Breast cancer usually starts in the glands that produce milk (lobules) or the tubes (ducts) that carry... read more Breast Cancer , stomach Stomach Cancer A Helicobacter pylori infection is a risk factor for stomach cancer. Vague abdominal discomfort, weight loss, and weakness are some typical symptoms. Diagnosis includes endoscopy and biopsy... read more Stomach Cancer , female reproductive organs Overview of Female Reproductive System Cancers Cancers can occur in any part of the female reproductive system—the vulva, vagina, cervix, uterus, fallopian tubes, or ovaries. These cancers are called gynecologic cancers. The most common... read more , intestine Tumors of the Digestive System read more , and pancreas Pancreatic Cancer Smoking, chronic pancreatitis, male sex, being black, and possibly long-standing diabetes are risk factors for pancreatic cancer. Abdominal pain, weight loss, jaundice, and vomiting are some... read more ; leukemia Overview of Leukemia Leukemias are cancers of white blood cells or of cells that develop into white blood cells. White blood cells develop from stem cells in the bone marrow. Sometimes the development goes awry... read more ; and lymphoma Overview of Lymphoma Lymphomas are cancers of lymphocytes, which reside in the lymphatic system and in blood-forming organs. Lymphomas are cancers of a specific type of white blood cells known as lymphocytes. These... read more Overview of Lymphoma .

Such spread usually does not cause symptoms. Spread is usually diagnosed when tests are done to determine how far the original cancer has spread. Treatment is usually directed at the original cancer. Occasionally, if the original cancer is treated and the tumor in the kidney is growing, the kidney tumor is removed.

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