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Brain Arteriovenous Malformations (AVMs)

By

Ji Y. Chong

, MD, Weill Cornell Medical College

Last full review/revision Jul 2020| Content last modified Jul 2020
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An arteriovenous malformation is a tangle of dilated blood vessels that directly connect arteries and veins, bypassing the capillaries (which normally connect arteries and veins).

  • Brain arteriovenous malformations (AVMs) may or may not cause bleeding in the brain.

  • They may cause headaches with or without bleeding in the brain.

  • Doctors do brain imaging to diagnose AVMs.

  • Treatment may involve surgery to remove the AVM, radiosurgery to destroy the AVM, placement of material to block the AVM's blood supply, or a combination of treatments, but observation is also an option..

Brain (cerebral) arteriovenous malformations (AVMs) are uncommon.

Bleeding due to AVMs usually occurs in brain tissue (intracerebral hemorrhage), but it may occur in the space (subarachnoid space) between the inner and middle layers of the tissues covering the brain (subarachnoid hemorrhage) or into the fluid-filled spaces within the brain.

AVMs can cause seizures or headache, typically in young adults. AVMs may cause headaches with no bleeding.

Diagnosis

  • Brain imaging

Doctors use brain imaging to diagnose brain arteriovenous malformations. Many brain AVMs can be detected by the following:

  • Computed tomography (CT), done after a radiopaque contrast agent (which can be seen on x-rays) is injected into a vein to make the aneurysm visible on an x-ray

  • Magnetic resonance imaging

However, cerebral angiography may be needed for definitive diagnosis and is required for planning treatment. For cerebral angiography, a thin, flexible tube (catheter) is inserted into an artery, usually in the groin, and threaded through the aorta to an artery in the neck. Then, a radiopaque contrast agent is injected to outline the artery. Cerebral angiography is more invasive than magnetic resonance angiography or CT angiography, but it provides more information.

Unruptured AVMs are often detected when brain imaging is done for other reasons.

Treatment

  • Conservative management

  • Microsurgery, radiosurgery, and/or endovascular surgery

For cerebral arteriovenous malformations, the primary goal of treatment is to prevent hemorrhagic stroke. The risks of various treatments must be weighed against the risks of no treatment (which may include rupture, seizures, and, rarely disabling brain damage).

Treatment options include

  • Microsurgery to remove the aneurysm

  • Stereotactic radiosurgery

  • Endovascular embolization

  • A combination of these procedures

  • No procedure

Doctors may recommend that no procedure be done if the risk of bleeding seems low or the risk of adverse effects from treatment seems high. In such cases, the aneurysm is regularly monitored for changes that could make rupture more likely.

People who have had a ruptured AVM are usually treated with a procedure to eliminate the AVM.

Microsurgery involves removing a piece of the skull so doctors can see the AVM. Then, using a microscope, they locate and remove the AVM.

Radiosurgery is not really surgery because no incision is required. Radiation is focused precisely on the AVM and used to destroy it. Machines, such as a gamma knife and a linear accelerator, are used to produce the radiation. When a gamma knife is used, an imaging frame is attached to the person’s skull. The person lies on a sliding bed, and a large helmet with holes in it is placed over the frame. The head of the bed is then slid into a globe that contains radioactive cobalt. Radiation passes through the holes in the helmet and is aimed precisely at the AVM. A linear accelerator circles the head of the person, who lies on a sliding bed, and aims radiation precisely at the AVM from different angles.

For endovascular embolization, a thin, flexible tube (catheter) is guided to the AVM and a device (such as a coil) or material is used to prevent blood from flowing into the AVM. Endovascular embolization does not repair the AVM, but it reduces blood flow to the AVM and makes surgery, if needed, safer. It may be done before microsurgery or stereotactic radiosurgery.

NOTE: This is the Consumer Version. DOCTORS: Click here for the Professional Version
Click here for the Professional Version
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