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Oxazolidinones: Linezolid and Tedizolid

By

Brian J. Werth

, PharmD, University of Washington School of Pharmacy

Last full review/revision Jul 2020| Content last modified Jul 2020
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NOTE: This is the Consumer Version. DOCTORS: Click here for the Professional Version
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Topic Resources

Oxazolidinones are a class of antibiotics used to treat serious infections, often after other antibiotics have been ineffective.

Oxazolidinones include the following:

  • Linezolid

  • Tedizolid

Oxazolidinones work by preventing bacteria from producing proteins they need to grow and multiply.

Table
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Oxazolidinones

Drug

Common Uses

Some Side Effects

Linezolid

Serious infections caused by susceptible gram-positive bacteria such as Staphylococcus (including methicillin-resistant Staphylococcus aureus [MRSA]), Streptococcus, and enterococci (including vancomycin-resistant enterococci) that are resistant to many other antibiotics

Nausea and diarrhea

Headache

Anemia and low white blood cell and platelet counts

Numbness and tingling in the hands and feet (peripheral neuropathy)

Visual disturbances

Serotonin syndrome (confusion, agitation, tremors, or coma) in some people who also take selective serotonin-reuptake inhibitors, monamine oxidase inhibitors, and some other drugs that affect serotonin levels.

Build up of lactic acid in the blood (lactic acidosis)

Tedizolid

Complicated skin infections due to susceptible bacteria, including MRSA

Gastrointestinal upset

Headache

Anemia and a low white blood cell count

Use of Linezolid and Tedizolid During Pregnancy and Breastfeeding

Linezolid and tedizolid should be used during pregnancy only if the benefits exceed the risk. (See also Drug Use During Pregnancy.)

Whether linezolid and tedizolid are safe to use during breastfeeding is unknown. (See also Drug Use During Breastfeeding.)

NOTE: This is the Consumer Version. DOCTORS: Click here for the Professional Version
Click here for the Professional Version

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