Деякі пероральні лікарські препарати для лікування диспепсії
Medication* | Comments |
|---|---|
Proton pump inhibitors | |
Dexlansoprazole | With long-term use, elevated gastrin levels, but no evidence that this finding causes dysplasia or cancer May cause abdominal pain or diarrhea |
Esomeprazole | |
Lansoprazole | |
Omeprazole | |
Pantoprazole | |
Rabeprazole | |
H2 blockers | |
Cimetidine | Doses reduced in older adults With cimetidine and to a lesser extent with other medications, minor antiandrogen effects and, less commonly, erectile dysfunction Delayed metabolism of medications eliminated by cytochrome P-450 enzyme system (eg, phenytoin, warfarin, diazepam) May cause constipation or diarrhea |
Famotidine | |
Nizatidine | |
Ranitidine† | |
Cytoprotective agent | |
Sucralfate | Rarely constipation May bind to other medications and interfere with absorption Cimetidine, ciprofloxacin, digoxin, norfloxacin, ofloxacin, and ranitidine† avoided 2 hours before or after taking sucralfate |
* Tricyclic antidepressants may help. Metoclopramide or erythromycin given as a liquid suspension also may be tried in patients with dysmotility-like dyspepsia. | |
† Ranitidine (oral, IV, and over the counter) has been removed from the market in the United States and in many other countries because of unacceptable concentrations of N-nitrosodimethylamine (NDMA), a probable human carcinogen. Cimetidine and famotidine are alternatives and do not contain NDMA, nor do proton pump inhibitors. | |