Alcohol use disorder involves a pattern of alcohol use that typically includes craving and manifestations of tolerance and/or withdrawal along with adverse psychosocial consequences. Alcoholism and alcohol abuse are common but less rigorously defined terms applied to people with problems related to alcohol.
Alcohol use disorder is quite common. It is estimated to be present in 13.9% of adults in the US in any 12-month period. Prevalence is highest among young adults and decreases with age. Among people age 18 to 29 years, the estimated 12-month prevalence of alcohol use disorder is 26.7% (1) General reference Alcohol use disorder involves a pattern of alcohol use that typically includes craving and manifestations of tolerance and/or withdrawal along with adverse psychosocial consequences. Alcoholism... read more , and that of severe alcohol use disorder is 7.1%, whereas for people ≥ 65 years, 12-month prevalence of alcohol use disorder is only 2.3%.
At-risk drinking is defined solely by quantity and frequency of drinking:
> 14 drinks/week or 4 drinks per occasion for men
> 7 drinks/week or 3 drinks per occasion for women
Compared with lesser amounts, these amounts are associated with increased risk of a wide variety of medical and psychosocial complications.
(See also Alcohol Toxicity and Withdrawal Alcohol Toxicity and Withdrawal Alcohol (ethanol) is a central nervous system depressant. Large amounts consumed rapidly can cause respiratory depression, coma, and death. Large amounts chronically consumed damage the liver... read more .)
Grant BF, Goldstein RB, Saha T, et al: Epidemiology of DSM-5 alcohol use disorder results from the National Epidemiologic Survey on Alcohol and Related Conditions III. JAMA Psychiatry 72(8):757–766, 2015. doi: 10.1001/jamapsychiatry.2015.0584
Etiology of Alcohol Use Disorders
The maladaptive pattern of drinking that constitutes alcohol abuse may begin with a desire to reach a state of feeling high. Some drinkers who find the feeling rewarding then focus on repeatedly reaching that state. Many who abuse alcohol chronically have certain personality traits: feelings of isolation, loneliness, shyness, depression, dependency, hostile and self-destructive impulsivity, and sexual immaturity.
Patients with alcohol use disorder may come from a broken home and have a disturbed relationship with their family. Societal factors—attitudes transmitted through the culture or child rearing—affect patterns of drinking and consequent behavior. In the US, alcohol use disorder is more common in men, whites, unmarried people, and certain nonwhite ethnic groups (eg, Native Americans). However, such generalizations should not obscure the fact that alcohol use disorders can occur in anyone, regardless of their age, sex, background, ethnicity, or social situation. Thus, clinicians should screen for alcohol problems in all patients.
As much as 40 to 60% of risk variance is thought to be due to genetic factors. The incidence of alcohol abuse and dependence is higher in biologic children of people with alcohol problems than in adoptive children in a given family (and also higher than in the general population). There is evidence of genetic or biochemical predisposition, including data that suggest some people who develop alcohol use disorder are less easily intoxicated; ie, they have a higher threshold for central nervous system effects.
Symptoms and Signs of Alcohol Use Disorders
Serious social consequences in patients with alcohol use disorder usually occur. Frequent intoxication is obvious and destructive; it interferes with the ability to socialize and work. Injuries are common. Eventually, failed relationships and job loss due to absenteeism may result.
People may be arrested because of alcohol-related behavior or be apprehended for driving while intoxicated, often losing driving privileges for repeated offenses. In the US, all states define driving with a blood alcohol content (BAC) at or above 80 mg/dL (0.08%, [17.4 mmol/L]) as a crime, but specific state laws and penalties vary.
Diagnosis of Alcohol Use Disorders
The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) considers alcohol use disorder to be present if patients have clinically significant impairment or distress as manifested by the presence of ≥ 2 of the following over a 12-month period:
Taking alcohol in larger amounts or for a longer time than intended
Persistently desiring or unsuccessfully attempting to decrease alcohol use
Spending a great deal of time obtaining, using, or recovering from alcohol
Failing repeatedly to meet obligations at work, home, or school because of alcohol
Continuing to use alcohol despite having recurrent social or interpersonal problems because of alcohol
Giving up important social, work, or recreational activities because of alcohol
Using alcohol in physically hazardous situations
Continuing to use alcohol despite having a physical disorder (eg, liver disease) or mental disorder (eg, depression) caused or worsened by alcohol
Having tolerance to alcohol
Having alcohol withdrawal Withdrawal Alcohol (ethanol) is a central nervous system depressant. Large amounts consumed rapidly can cause respiratory depression, coma, and death. Large amounts chronically consumed damage the liver... read more symptoms or drinking alcohol because of withdrawal
Some alcohol-related problems are diagnosed when people seek medical treatment for their drinking or for obvious alcohol-related illness (eg, delirium tremens Withdrawal Alcohol (ethanol) is a central nervous system depressant. Large amounts consumed rapidly can cause respiratory depression, coma, and death. Large amounts chronically consumed damage the liver... read more , cirrhosis Cirrhosis Cirrhosis is a late stage of hepatic fibrosis that has resulted in widespread distortion of normal hepatic architecture. Cirrhosis is characterized by regenerative nodules surrounded by dense... read more ). However, many of these people remain unrecognized for a long time. Female patients with alcohol use disorder are, in general, more likely to drink alone and are less likely to manifest some of the social signs. Therefore, many governmental and professional organizations recommend alcohol screening during routine health care visits.
A scaled approach (see see Table: Levels of Screening for Alcohol Problems Levels of Screening for Alcohol Problems Alcohol use disorder involves a pattern of alcohol use that typically includes craving and manifestations of tolerance and/or withdrawal along with adverse psychosocial consequences. Alcoholism... read more ) can help identify patients who require more detailed questioning. Several validated detailed questionnaires are available, including the AUDIT (Alcohol Use Disorders Identification Test) and the CAGE questionnaire.
Treatment of Alcohol Use Disorders
Consideration of drugs (eg, naltrexone, disulfiram, acamprosate)
All patients should be counseled to decrease their alcohol use to below at-risk levels.
For patients identified as at-risk drinkers, treatment may begin with a brief discussion of the medical and social consequences and a recommendation to reduce or cease drinking, with follow-up regarding compliance (see table Brief Interventions for Alcohol Problems Brief Interventions for Alcohol Problems Alcohol use disorder involves a pattern of alcohol use that typically includes craving and manifestations of tolerance and/or withdrawal along with adverse psychosocial consequences. Alcoholism... read more ).
For patients with more serious problems, particularly after less intensive measures have been unsuccessful, a rehabilitation program is often the best approach. Rehabilitation programs combine psychotherapy, including one-on-one and group therapy, with medical supervision. For most patients, outpatient rehabilitation is sufficient; how long patients remain enrolled in programs varies, typically weeks to months, but longer if needed.
Inpatient rehabilitation programs are reserved for patients with more severe alcohol dependence and those with significant and comorbid medical, psychoactive, and substance abuse problems. Treatment duration is usually briefer (typically days to weeks) than that of outpatient programs and may be dictated in part by patients’ insurance.
Psychotherapy involves techniques that enhance motivation and teach patients to avoid circumstances that precipitate drinking. Social support of abstinence, including the support of family and friends, is important.
Maintaining sobriety is difficult. Patients should be warned that after a few weeks, when they have recovered from their last bout, they are likely to find an excuse to drink. They should also be told that although they may be able to practice controlled drinking for a few days or, rarely, a few weeks, they will most likely lose control eventually.
In addition to the counseling provided in outpatient and inpatient alcohol treatment programs, self-help groups and certain drugs may help prevent relapse in some patients.
Alcoholics Anonymous (AA) is the most common self-help group. Patients must find an AA group they feel comfortable in. AA provides patients with nondrinking friends who are always available and a nondrinking environment in which to socialize. Patients also hear others discuss every rationalization they have ever used for their own drinking. The help they give other patients with alcohol use disorder may give them the self-regard and confidence formerly found only in alcohol. Many patients with alcohol use disorder are reluctant to go to AA and find individual counseling or group or family treatment more acceptable. Alternative organizations, such as LifeRing Secular Recovery (Secular Organizations for Sobriety), exist for patients seeking another approach.
Drug therapy should be used with counseling rather than as the sole treatment. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) provides a guide for clinicians on medical management and pharmacotherapy for alcohol dependence—as does the American Psychiatric Association—along with a number of other publications and resources for both health care practitioners and patients.
Disulfiram, the first drug available to prevent relapse in alcohol dependence, interferes with the metabolism of acetaldehyde (an intermediary product in the oxidation of alcohol) so that acetaldehyde accumulates. Drinking alcohol within 12 hours of taking disulfiram causes facial flushing in 5 to 15 minutes, then intense vasodilation of the face and neck with suffusion of the conjunctivae, throbbing headache, tachycardia, hyperpnea, and sweating. With high doses of alcohol, nausea and vomiting may follow in 30 to 60 minutes and may lead to hypotension, dizziness, and sometimes fainting and collapse. The reaction can last up to 3 hours. Few patients risk drinking alcohol while taking disulfiram because of the intense discomfort. Drugs that contain alcohol (eg, tinctures; elixirs; some OTC liquid cough and cold preparations, which contain as much as 40% alcohol) must also be avoided.
Disulfiram is contraindicated during pregnancy and in patients with cardiac decompensation. It may be given on an outpatient basis after 4 or 5 days of abstinence. The initial dosage is 0.5 g orally once/day for 1 to 3 weeks, followed by a maintenance dosage of 0.25 g once/day. Effects may persist for 3 to 7 days after the last dose. Periodic physician visits are needed to encourage continuation of disulfiram as part of an abstinence program.
Disulfiram’s general usefulness has not been established, and many patients are nonadherent. Adherence usually requires adequate social support, such as observation of drinking. For these reasons, use of disulfiram is now limited. Disulfiram is most effective when given under close supervision to highly motivated patients.
Naltrexone, an opioid antagonist, decreases the relapse rate and number of drinking days in most patients who take it consistently. Naltrexone 50 mg orally once/day is typically given, although there is evidence that higher doses (eg, 100 mg once/day) may be more effective in some patients. Even with counseling, adherence rates with oral naltrexone are modest. A long-acting depot form is also available: 380 mg IM once/month. Naltrexone is contraindicated in patients with acute hepatitis Overview of Acute Viral Hepatitis Acute viral hepatitis is diffuse liver inflammation caused by specific hepatotropic viruses that have diverse modes of transmission and epidemiologies. A nonspecific viral prodrome is followed... read more or liver failure Acute Liver Failure Acute liver failure is caused most often by drugs and hepatitis viruses. Cardinal manifestations are jaundice, coagulopathy, and encephalopathy. Diagnosis is clinical. Treatment is mainly supportive... read more and in those who are opioid dependent.
Clonidine, the oldest alpha-2-agonist, given orally or transdermally has proved successful in reducing symptoms of alcohol withdrawal, particularly hypertension and tachycardia, in patients with mild-to-moderate withdrawal. However, there is evidence that clonidine is effective as monotherapy to prevent alcohol withdrawal seizures or alcohol withdrawal delirium.
Acamprosate, a synthetic analogue of gamma-aminobutyric acid, is given as 2 g orally once/day. Acamprosate may decrease the relapse rate and number of drinking days in patients who relapse.
Nalmefene, an opioid antagonist, and topiramate are under study for their ability to decrease alcohol craving.
Findtreatment.gov: Listing of licensed US providers of treatment for substance use disorders