Sudden infant death syndrome (SIDS) is the most common cause of death of infants between 2 weeks and 1 year of age, accounting for 35 to 55% of all deaths in this age group. The rate of SIDS occurrence is 0.5/1000 births in the US; there are racial and ethnic disparities (African American and Native American children have twice the average risk of SIDS). Peak incidence is between the 2nd and 4th months of life. Almost all SIDS deaths occur when the infant is thought to be sleeping.
Etiology of SIDS
The cause of SIDS is unknown, although it is most likely due to dysfunction of neural cardiorespiratory control mechanisms. The dysfunction may be intermittent or transient, and multiple mechanisms are probably involved. Factors that may be involved are the infant having a poor sleep arousal mechanism, an inability to detect elevated CO2 levels in the blood, or a cardiac channelopathy that affects heart rhythm.
Fewer than 5% of infants with SIDS have episodes of prolonged apnea before their death, so the overlap between the SIDS population and infants with recurrent prolonged apnea is very small.
Risk factors for SIDS
The definite association between a prone (on stomach) sleeping position and an increased risk of SIDS has been documented strongly.
Other risk factors (see Table: Risk Factors for Sudden Infant Death Syndrome Risk Factors for Sudden Infant Death Syndrome ) include old or unsafe cribs, soft bedding (eg, lamb’s wool), waterbed mattresses, bed-sharing Sleeping in Infants and Children with a parent/caregiver, smoking in the home, and an overheated environment. Siblings of infants who die of SIDS are 5 times more likely to die of SIDS; it is not clear whether this is related to genetics or environment (including possible abuse by the affected infant's family).
Many risk factors for SIDS apply to non-SIDS infant deaths as well.
Diagnosis of SIDS
Exclusion of other causes by autopsy
The diagnosis of SIDS, while largely one of exclusion, cannot be made without an adequate autopsy to rule out other causes of sudden, unexpected death (eg, intracranial hemorrhage, meningitis, myocarditis). An autopsy may be required in many states. Also, the care team (including social workers) should sensitively assess the likelihood of infant suffocation or nonaccidental trauma (see Overview of Child Maltreatment Overview of Child Maltreatment Child maltreatment is behavior toward a child that is outside the norms of conduct and entails substantial risk of causing physical or emotional harm. Four types of maltreatment are generally... read more ); concern for this etiology should increase when the affected infant was outside the highest-risk age group (1 to 5 months) or another infant in the family had SIDS or frequent brief, resolved, unexplained events BRUE and ALTE BRUE (brief, resolved, unexplained event) and ALTE (apparent life-threatening event) are not specific disorders but terms for a group of alarming symptoms that can occur in infants. They involve... read more (BRUEs).
Management of SIDS
Parents who have lost a child to SIDS are grief-stricken and unprepared for the tragedy. Because no definitive cause can be found for their child’s death, they usually have excessive guilt feelings, which may be aggravated by investigations conducted by police, social workers, or others. Family members require support not only during the days immediately after the infant’s death but for at least several months to help them with their grief and dispel guilt feelings. Such support includes, whenever possible, an immediate home visit to observe the circumstances in which SIDS occurred and to inform and counsel the parents concerning the cause of death.
Autopsy should be done quickly. As soon as the preliminary results are known (usually within 12 hours), they should be communicated to the parents. Some clinicians advise a series of home or office visits over the first month to continue the earlier discussions, answer questions, and give the family the final (microscopic) autopsy results. At the last meeting, it is appropriate to discuss the parents’ adjustment to their loss, especially their attitude toward having other children. Much of the counseling and support can be complemented by specially trained nurses or by lay people who have themselves experienced the tragedy of and adjustment to SIDS (visit the American SIDS Institute for more information and resources).
Prevention of SIDS
The American Academy of Pediatrics (see SIDS and Other Sleep-Related Infant Deaths: Expansion of Recommendations for a Safe Infant Sleeping Environment) recommends that infants be placed supine (on their back—see the Safe to Sleep® campaign) for sleep unless other medical conditions prevent this. Side sleeping or propping is too unstable. The incidence of SIDS increases with overheating (eg, clothing, blankets, hot room) and in cold weather. Thus, every effort should be made to avoid an overly hot or an overly cold environment, to avoid overwrapping the infant, and to remove soft bedding, such as sheepskin, pillows, stuffed toys/animals, and comforters, from the crib. Pacifiers may be helpful, because they help open the airway. Parents/caregivers should not have the infant sleep in their bed.
To help prevent flat spots from developing on the infant's head, infants should spend some time on their tummy when they are awake and someone is watching them. To help make the infant's head round, parents should change the direction that the infant lies in while in the crib each week and avoid leaving the infant for too long in car seats, carriers, and bouncers.
Mothers should avoid smoking during pregnancy, and infants should not be exposed to smoke. Breastfeeding is encouraged to help prevent infections.
There is no evidence that home apnea monitors reduce the incidence of SIDS and therefore are not suggested for prevention.
Specific causes, including child abuse, must be ruled out by clinical evaluation and autopsy.
Etiology is unclear, although a number of risk factors have been identified.
The most important modifiable risk factors involve the sleep setting, particularly prone sleeping, along with avoidance of bed-sharing and sleeping on very soft surfaces or with loose bedding.
Apneic episodes and brief, resolved, unexplained events (BRUEs) do not appear to be risk factors.
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