MSD Manual

Please confirm that you are a health care professional

Loading

Pineal Region Tumors

By

Steven A. Goldman

, MD, PhD, University of Rochester Medical Center;


Nimish A. Mohile

, MD, University of Rochester Medical Center

Last full review/revision Jun 2018| Content last modified Jun 2018
Click here for Patient Education
NOTE: This is the Professional Version. CONSUMERS: Click here for the Consumer Version

Most pineal region tumors are germ cell tumors.

Common primary pineal region tumorsinclude germ cell tumors:

  • Germinomas (most common)

  • Choriocarcinomas

  • Yolk-sac tumors

  • Teratomas

Less common primary pineal tumors include pineocytomas and the rare malignant pineoblastomas.

Pineal region tumors tend to occur during childhood but can occur at any age.

These tumors may increase intracranial pressure by compressing the aqueduct of Sylvius. They may also cause paresis of upward gaze, ptosis, and loss of pupillary light and accommodation reflexes by compressing the pretectum rostral to the superior colliculi (Parinaud syndrome). These tumors may cause precocious puberty, especially in boys, probably because the hypothalamus is compressed.

CSF beta-human chorionic gonadotropin or alpha-fetoprotein may be elevated, depending on the tumor type. Elevated levels suggest the diagnosis; levels may be measured to monitor response to treatment.

Prognosis and treatment depend on tumor histology. Radiation therapy, chemotherapy, radiosurgery, and surgery are used alone or in combination. Germinomas are very sensitive to radiation therapy and are often cured.

Click here for Patient Education
NOTE: This is the Professional Version. CONSUMERS: Click here for the Consumer Version
Professionals also read

Also of Interest

Videos

View All
Overview of Epilepsy
Video
Overview of Epilepsy
3D Models
View All
Brain Vasculature
3D Model
Brain Vasculature

SOCIAL MEDIA

TOP