Toxic Causes of Polyneuropathies

Axonal motor

Tetanus, tick paralysis

With prolonged exposure, lead, mercury

Axonal sensorimotor

Acrylamide, alcohol (ethanol), allyl chloride, arsenic, cadmium, carbon disulfide, chlorphenoxy compounds, ciguatoxin, colchicine, cyanide, dapsone, disulfiram, DMAPN, ethylene oxide, lithium, methyl bromide, nitrofurantoin, organophosphates, PCBs, PNU, podophyllin, saxitoxin, Spanish toxic oil, taxol, tetrodotoxin, thallium, trichloroethylene, TOCP, vinca alkaloidsAcrylamide, alcohol (ethanol), allyl chloride, arsenic, cadmium, carbon disulfide, chlorphenoxy compounds, ciguatoxin, colchicine, cyanide, dapsone, disulfiram, DMAPN, ethylene oxide, lithium, methyl bromide, nitrofurantoin, organophosphates, PCBs, PNU, podophyllin, saxitoxin, Spanish toxic oil, taxol, tetrodotoxin, thallium, trichloroethylene, TOCP, vinca alkaloids

Axonal sensory

Almitrine, bortezomib, chloramphenicol, dioxin, doxorubicin, ethambutol, ethionamide, etoposide, gemcitabine, glutethimide, hydralazine, ifosfamide, interferon alfa, isoniazid, lead, metronidazole, misonidazole, nitrous oxide, nucleosides (didanosine [ddI], stavudine [d4T], zalcitabine [ddC]), phenytoin, platinum analogs, propafenone, pyridoxine, statins, thalidomideAlmitrine, bortezomib, chloramphenicol, dioxin, doxorubicin, ethambutol, ethionamide, etoposide, gemcitabine, glutethimide, hydralazine, ifosfamide, interferon alfa, isoniazid, lead, metronidazole, misonidazole, nitrous oxide, nucleosides (didanosine [ddI], stavudine [d4T], zalcitabine [ddC]), phenytoin, platinum analogs, propafenone, pyridoxine, statins, thalidomide

Demyelinating

Buckthorn, immune checkpoint inhibitors, chloroquine, diphtheria, hexachlorophene, muzolimine, perhexiline, procainamide, tacrolimus tellurium, zimeldineBuckthorn, immune checkpoint inhibitors, chloroquine, diphtheria, hexachlorophene, muzolimine, perhexiline, procainamide, tacrolimus tellurium, zimeldine

Mixed

Amiodarone, ethylene glycol, gold, hexacarbons, Amiodarone, ethylene glycol, gold, hexacarbons,n-hexane, sodium cyanate, suramin