Selected Antiretroviral (ARV) Regimens for Initial Therapy of HIV Infection in Children*
Age Group | NRTI Backbone Component (Use 2) | NNRTI, PI, or INSTI Component (Use 1) |
|---|---|---|
Infants birth to < 14 days | Zidovudine Zidovudineplus lamivudine (or emtricitabine)lamivudine (or emtricitabine) | Nevirapine Nevirapineor Weight ≥ 2 kg: RaltegravirWeight ≥ 2 kg: Raltegravir |
Children ≥ 14 days to < 4 weeks | Zidovudine Zidovudineplus lamivudine (or emtricitabine) lamivudine (or emtricitabine) | Lopinavir/ritonavir Lopinavir/ritonaviror Weight ≥ 2 kg: RaltegravirWeight ≥ 2 kg: Raltegravir |
Children ≥ 4 weeks, weight > 3 kg | Abacavir (or zidovudine) Abacavir (or zidovudine)plus lamivudine (or emtricitabine)lamivudine (or emtricitabine) | DolutegravirDolutegravir Weight > 25 kg: A fixed-dose tablet of abacavir/lamivudine/dolutegravir is available as a complete once-daily regimen.Weight > 25 kg: A fixed-dose tablet of abacavir/lamivudine/dolutegravir is available as a complete once-daily regimen. |
Children ≥ 2 years, weight ≥ 14 kg | Emtricitabine Emtricitabineplus tenofovir alafenamidetenofovir alafenamide | Bictegravir A fixed-dose tablet of emtricitabine/tenofovir alafenamide/bictegravir (available in two dosing strengths) is available as a complete once-daily regimen.A fixed-dose tablet of emtricitabine/tenofovir alafenamide/bictegravir (available in two dosing strengths) is available as a complete once-daily regimen. |
Adolescents > 12 years, weight ≥ 25 kg | Emtricitabine Emtricitabineplus tenofovir alafenamidetenofovir alafenamide | Bictegravir A fixed-dose tablet of emtricitabine/tenofovir alafenamide/bictegravir is available as a complete once-daily regimen.A fixed-dose tablet of emtricitabine/tenofovir alafenamide/bictegravir is available as a complete once-daily regimen. |
* Each regimen is designed to contain 2 NRTI antiretroviral (ARV) medications plus either an NNRTI, PI, or INSTI component. Several alternative ARV regimens exist; consultation with an expert in pediatric HIV medicine is advised. For information on adverse effects, other doses (especially for information on fixed-dose combination products), and drug interactions, see the continually updated Panel on Antiretroviral Therapy and Medical Management of Children Living with HIV's Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection. Accessed 02/08/2023. | ||
INSTI = integrase strand transfer inhibitor; NNRTI = non-nucleoside reverse transcriptase inhibitor; NRTI = nucleoside/nucleotide reverse transcriptase inhibitor; PI = protease inhibitor. | ||