Clinical Staging of Chronic Lymphocytic Leukemia*
Classification and Stage | Description |
|---|---|
Rai | |
Stage 0 | Absolute lymphocytosis of > 10,000/mcL (> 10 × 109/L) in blood and ≥ 30% lymphocytes in bone marrow |
Stage I | Stage 0 plus enlarged lymph nodes |
Stage II | Stage 0–I plus hepatomegaly or splenomegaly |
Stage III | Stage 0–II plus anemia with hemoglobin < 11 g/dL (< 110 g/L) |
Stage IV | Stage 0–III plus thrombocytopenia with platelet counts <100,000/mcL (< 100 × 109/L) |
Binet | |
Stage A | Absolute lymphocytosis of > 10,000/mcL (> 10 × 109/L) in blood and ≥ 30% lymphocytes in bone marrow Hemoglobin ≥ 10 g/dL ( ≥ 100 g/L) Platelets ≥100,000/mcL (≥ 100 × 109/L) ≤ 2 involved sites* |
Stage B | As for stage A, but 3–5 involved sites |
Stage C | As for stage A or B, but hemoglobin < 10 g/dL (< 100 g/L) or platelets < 100,000/mcL (100 × 109/L) |
* Sites considered: Cervical, axillary, and inguinal lymph nodes; liver; and spleen. Rai KR, Sawitsky A, Cronkite EP, et al. Clinical staging of chronic lymphocytic leukemia. Blood. 1975;46(2):219-234. Blood. 2016;128(17):2109. doi:10.1182/blood-2016-08-737650 Binet JL, Auquier A, Dighiero G, et al. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer. 1981;48(1):198-206. doi:10.1002/1097-0142(19810701)48:1<198::aid-cncr2820480131>3.0.co;2-v | |