Antiretroviral Management for Infants With In Utero or Intrapartum HIV Exposure by Risk of HIV Transmission

Antiretroviral Management for Infants With In Utero or Intrapartum HIV Exposure by Risk of HIV Transmission

* Early (acute or recent) HIV infection in pregnancy may result in a situation where viremia occurs early in gestation but is suppressed after 20 weeks and through the remainder of pregnancy until delivery. In this situation, decision making guided by the clinical scenario is recommended. See table Neonatal Antiretroviral Management According to Risk of HIV Infection .

† ZDV prophylaxis is administered for 6 weeks total even if other medications are given for a shorter duration.

‡ If birth HIV NAT is negative.

NAT = nucleic acid test; PCR = polymerase chain reaction; ZDV = zidovudine.

Data from Panel on Antiretroviral Therapy and Medical Management of Children Living With HIV. Recommendations for the Use of Antiretroviral Drugs During Pregnancy and Interventions to Reduce Perinatal HIV Transmission in the United States. Care of Infants With Perinatal Exposure to HIV. December 19, 2024. Accessed June 19, 2025.