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Vitamin B6 Excess

(Vitamin B6 Toxicity)

By

Larry E. Johnson

, MD, PhD, University of Arkansas for Medical Sciences

Last full review/revision Nov 2020| Content last modified Nov 2020
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Vitamin B6 toxicity is rare but can result from taking high doses of vitamin B6 supplements.

Good sources of vitamin B6 include dried yeast, liver, other organ meats, whole-grain cereals, fish, and legumes.

Vitamin B6 in very high doses may be prescribed for such disorders as carpal tunnel syndrome or premenstrual syndrome, although there is little evidence of benefit.

Taking very high doses of vitamin B6 may damage the nerves (called neuropathy Polyneuropathy Polyneuropathy is the simultaneous malfunction of many peripheral nerves throughout the body. Infections, toxins, drugs, cancers, nutritional deficiencies, diabetes, autoimmune disorders, and... read more ), causing pain and numbness in the feet and legs. People may be unable to tell where their arms and legs are (position sense) and to feel vibrations. Thus, walking becomes difficult.

The diagnosis of vitamin B6 toxicity is based on symptoms and a history of taking high doses of vitamin B6.

Treatment of vitamin B6 toxicity involves stopping vitamin B6 supplements. Recovery from this disorder may be slow, and people may continue to have some difficulty walking.

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Test your knowledge

Riboflavin Deficiency
Riboflavin (vitamin B2) is essential for the processing (metabolism) of carbohydrates and amino acids. Which of the following does NOT increase risk of riboflavin deficiency?
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