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Autoimmune Disorders


James Fernandez

, MD, PhD, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University

Reviewed/Revised Oct 2022
Topic Resources

An autoimmune disorder is a malfunction of the body's immune system that causes the body to attack its own tissues.

  • What triggers an autoimmune disorder is not known.

  • Symptoms vary depending on which disorder develops and which part of the body is affected.

  • Several blood tests are often used to check for an autoimmune disorder.

  • Treatment depends on the type of autoimmune disorder and often involves drugs that suppress the activity of the immune system.

The immune system Overview of the Immune System The immune system is designed to defend the body against foreign or dangerous invaders. Such invaders include Microorganisms (commonly called germs, such as bacteria, viruses, and fungi) Parasites... read more must first recognize foreign or dangerous substances before it can defend the body against them Plan of Action The immune system is designed to defend the body against foreign or dangerous invaders. Such invaders include Microorganisms (commonly called germs, such as bacteria, viruses, and fungi) Parasites... read more . Such substances include bacteria, viruses, parasites (such as worms), certain cancer cells, and even transplanted organs and tissues. These substances have molecules that the immune system can identify and that can stimulate a response by the immune system. These molecules are called antigens. Antigens may be contained within cells or on the surface of cells (such as bacteria or cancer cells) or be part of a virus. Some antigens, such as pollen or food molecules, exist on their own.

When certain white blood cells (B cells B cells One of the body's lines of defense ( immune system) involves white blood cells (leukocytes) that travel through the bloodstream and into tissues, searching for and attacking microorganisms and... read more B cells and T cells T cells One of the body's lines of defense ( immune system) involves white blood cells (leukocytes) that travel through the bloodstream and into tissues, searching for and attacking microorganisms and... read more T cells ) encounter an antigen, they learn how to attack it and thus defend the body from the potentially dangerous antigen. B cells produce antibodies, which are one of the body's main immune defenses against antigens. Antibodies tightly bind to a specific antigen and tag it for attack or directly neutralize it. The body produces thousands of different antibodies. Each antibody is specific to a particular antigen. Cells of the immune system remember the specific antigen so that they can attack it even more efficiently the next time they encounter it.

Cells in a person's own tissues also have antigens. But normally, the immune system reacts only to antigens from foreign or dangerous substances, not to antigens from a person's own tissues. However, the immune system sometimes malfunctions, interpreting the body's own tissues as foreign and producing antibodies (called autoantibodies) or immune cells that target and attack particular cells or tissues of the body. This response is called an autoimmune reaction. It results in inflammation and tissue damage. Such effects may constitute an autoimmune disorder, but many people produce such small amounts of autoantibodies that an autoimmune disorder does not occur. Having autoantibodies Testing in the blood does not mean that a person has an autoimmune disorder.

Autoimmune Disorders

There are many autoimmune disorders. Some of the more common autoimmune disorders include Graves disease Causes Causes , rheumatoid arthritis Rheumatoid Arthritis (RA) Rheumatoid arthritis is an inflammatory arthritis in which joints, usually including those of the hands and feet, are inflamed, resulting in swelling, pain, and often destruction of joints.... read more Rheumatoid Arthritis (RA) , Hashimoto thyroiditis Hashimoto Thyroiditis Hashimoto thyroiditis is chronic, autoimmune inflammation of the thyroid gland. Hashimoto thyroiditis results when antibodies in the body attack the cells of the thyroid gland—an autoimmune... read more , type 1 diabetes mellitus Type 1 diabetes Diabetes mellitus is a disorder in which the body does not produce enough or respond normally to insulin, causing blood sugar (glucose) levels to be abnormally high. Symptoms of diabetes may... read more , systemic lupus erythematosus Systemic Lupus Erythematosus (SLE) Systemic lupus erythematosus is a chronic autoimmune inflammatory connective tissue disorder that can involve joints, kidneys, skin, mucous membranes, and blood vessel walls. Problems in the... read more Systemic Lupus Erythematosus (SLE) (lupus), and vasculitis Overview of Vasculitis Vasculitic disorders are caused by inflammation of the blood vessels (vasculitis). Vasculitis can be triggered by certain infections or drugs or can occur for unknown reasons. People may have... read more Overview of Vasculitis . Additional disorders that are believed to be autoimmune include Addison disease Adrenal Insufficiency In adrenal insufficiency, the adrenal glands do not produce enough adrenal hormones. Adrenal insufficiency may be caused by a disorder of the adrenal glands, a disorder of the pituitary gland... read more Adrenal Insufficiency , polymyositis Autoimmune Myositis Autoimmune myositis causes inflammation and weakness in the muscles (polymyositis) or in the skin and muscles (dermatomyositis). Muscle damage may cause muscle pain and muscle weakness may cause... read more Autoimmune Myositis , Sjögren syndrome Sjögren Syndrome Sjögren syndrome is a common autoimmune connective tissue disorder and is characterized by excessive dryness of the eyes, mouth, and other mucous membranes. White blood cells can infiltrate... read more Sjögren Syndrome , progressive systemic sclerosis Systemic Sclerosis Systemic sclerosis is a rare, chronic autoimmune connective tissue disorder characterized by degenerative changes and scarring in the skin, joints, and internal organs and by blood vessel abnormalities... read more Systemic Sclerosis , many cases of glomerulonephritis Glomerulonephritis Glomerulonephritis is a disorder of glomeruli (clusters of microscopic blood vessels in the kidneys with small pores through which blood is filtered). It is characterized by body tissue swelling... read more (inflammation of the kidneys), and some cases of infertility Overview of Infertility Infertility is a disease defined by the inability to achieve a pregnancy and/or the need for medical intervention to achieve a successful pregnancy. Infertility is defined as disease by the... read more Overview of Infertility .


Causes of Autoimmune Disorders

Autoimmune reactions can be triggered in several ways:

Why something triggers an autoimmune reaction or disorder in one person (and not another) is usually unknown. However, heredity is sometimes involved. Some people have genes that make them slightly more likely to develop an autoimmune disorder. This slightly increased susceptibility to an autoimmune disorder, rather than the disorder itself, is inherited. In susceptible people, a trigger, such as a viral infection or tissue damage, may cause the disorder to develop.

Many autoimmune disorders are more common among women.

Symptoms of Autoimmune Disorders

Symptoms vary depending on the disorder and the part of the body affected. Some autoimmune disorders affect certain types of tissue throughout the body—for example, blood vessels, cartilage, or skin. Other autoimmune disorders affect a particular organ. Virtually any organ, including the kidneys, lungs, heart, and brain, can be affected. The resulting inflammation and tissue damage can cause pain, deformed joints, weakness, jaundice, itching, difficulty breathing, accumulation of fluid (edema), delirium, and even death.

Diagnosis of Autoimmune Disorders

  • Blood tests

Doctors suspect an autoimmune disorder based on a person's symptoms. To help confirm the diagnosis, doctors do several laboratory tests.

Blood tests that indicate the presence of inflammation may suggest an autoimmune disorder. Such tests include the following:

  • The erythrocyte sedimentation rate (ESR): This test measures how quickly red blood cells (erythrocytes) settle to the bottom of a test tube containing blood. When inflammation is present, the ESR is often increased because proteins that are produced in response to inflammation interfere with the ability of red blood cells to remain suspended in blood.

  • Complete blood count (CBC): This test includes determining the number of red blood cells in blood. This number is frequently decreased (anemia) because fewer red blood cells are produced when inflammation is present.

Because inflammation has many causes (many of which are not autoimmune), doctors often also do blood tests to detect different antibodies that can occur in people who have particular autoimmune disorders. Examples of these antibodies are

But even these antibodies sometimes occur in people who do not have an autoimmune disorder, so doctors usually use a combination of test results and the person's symptoms to decide whether an autoimmune disorder is present.

Did You Know...

  • Some people have genes that make them slightly more likely to develop an autoimmune disorder.

  • Virtually any organ can be affected by an autoimmune disorder.

Prognosis for Autoimmune Disorders

Some autoimmune disorders resolve as inexplicably as they began. However, most autoimmune disorders are chronic. Drugs are often required throughout life to control symptoms.

The prognosis varies depending on the disorder.

Treatment of Autoimmune Disorders

  • Drugs that suppress the immune system, including corticosteroids

  • For some autoimmune disorders, plasma exchange and intravenous immune globulin

Drug treatment

Drugs that suppress the immune system Drugs Used to Prevent Transplant Rejection Drugs Used to Prevent Transplant Rejection (immunosuppressants), such as azathioprine, chlorambucil, cyclophosphamide, cyclosporine, mycophenolate, and methotrexate, are often given, usually by mouth and often for a long time. However, these drugs suppress not only the autoimmune reaction but also the body's ability to defend itself against foreign substances, including microorganisms that cause infection and cancer cells. Consequently, the risk of certain infections and cancers increases.

Often, corticosteroids Corticosteroids: Uses and Side Effects Corticosteroids: Uses and Side Effects , such as prednisone, are given, usually by mouth. These drugs relieve inflammation as well as suppress the immune system. Corticosteroids given for a long time have many side effects. When possible, corticosteroids are used for a short time—when the disorder begins or when symptoms worsen. However, corticosteroids must sometimes be used indefinitely.

Certain autoimmune disorders (such as multiple sclerosis and thyroid disorders) are also treated with drugs other than immunosuppressants and corticosteroids. Treatment to relieve symptoms may also be needed.

Certain drugs specifically target white blood cells. White blood cells help defend the body against infection but also participate in autoimmune reactions. These drugs include the following:

Other drugs that target white blood cells are being developed.

Plasma exchange and intravenous immune globulin

Plasma exchange Plateletpheresis (platelet donation) In addition to normal blood donation and transfusion, special procedures are sometimes used. In plateletpheresis, a donor gives only platelets rather than whole blood. Whole blood is drawn from... read more is used to treat a few autoimmune disorders. Blood is withdrawn and filtered to remove abnormal proteins such as autoantibodies. Then the filtered blood is returned to the person.

Intravenous immune globulin (a purified solution of antibodies obtained from volunteer donors and given by vein) is used to treat a few autoimmune disorders. How it works is unknown.

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