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Optic Neuritis


James Garrity

, MD, Mayo Clinic College of Medicine and Science

Last full review/revision Sep 2021| Content last modified Sep 2022
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Optic neuritis is inflammation of the optic nerve. Symptoms are usually unilateral, with eye pain and partial or complete vision loss. Diagnosis is primarily clinical. Treatment is directed at the underlying condition; most cases resolve spontaneously.

Etiology of Optic Neuritis

Optic neuritis is most common among adults 20 to 40 years. Most cases result from demyelinating disease, particularly multiple sclerosis Multiple Sclerosis (MS) Multiple sclerosis (MS) is characterized by disseminated patches of demyelination in the brain and spinal cord. Common symptoms include visual and oculomotor abnormalities, paresthesias, weakness... read more Multiple Sclerosis (MS) , in which case there may be recurrences. Optic neuritis is often the presenting manifestation of multiple sclerosis. Other causes include:

General references

  • 1. Chen JJ, Pittock SJ, Flanagan EP, et al: Optic neuritis in the era of biomarkers. Surv Ophthalmol 165(1):12-17, 2020. doi: 10.1016/j.survophthal.2019.08.001

  • 2. Chen JJ, Bhatti MT: Clinical phenotype, radiological features, and treatment of myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG) optic neuritis. Curr Opin Neurol;33(1):47-54, 2020. doi: 10.1097/WCO.0000000000000766

Symptoms and Signs of Optic Neuritis

The main symptom of optic neuritis is vision loss, frequently maximal within 1 or 2 days and varying from a small central or paracentral scotoma to complete blindness. Most patients have mild eye pain, which often feels worse with eye movement.

If the optic disk is swollen, the condition is called papillitis. If the optic disk appears normal, the condition is called retrobulbar neuritis. The most characteristic findings include reduced visual acuity, a visual field deficit, and disturbed color vision (often out of proportion to loss of visual acuity). An afferent pupillary defect is usually detectable if the contralateral eye is unaffected or involved to a lesser degree. Testing of color vision is a useful adjunct, although 10% of males have congenital color blindness, producing false-positive results. In about two thirds of patients, inflammation is entirely retrobulbar, causing no visible changes to the optic nerve head. In the rest, disk hyperemia, edema in or around the disk, vessel engorgement, or a combination is present. A few exudates and hemorrhages may be present near or on the optic disk.

Diagnosis of Optic Neuritis

  • Clinical evaluation

  • Magnetic resonance imaging (MRI)

Optic neuritis is suspected in patients with characteristic pain and vision loss, particularly if they are young. Neuroimaging, preferably with gadolinium-enhanced MRI of the brain and orbits, is usually done and may show an enlarged, enhancing optic nerve. MRI may also help diagnose multiple sclerosis, myelin oligodendrocyte glycoprotein autoantibody (MOG-IgG) disease, and neuromyelitis optica (NMO). Fluid attenuating inversion recovery (FLAIR) MRI sequences may show typical demyelinating lesions in a periventricular location if optic neuritis is related to demyelination. Spinal cord involvement can be seen in NMO or MOG-IgG disease.

Pearls & Pitfalls

  • Consider gadolinium-enhanced MRI for young patients who have eye pain with movement and loss of vision (eg, decreased visual acuity or color vision, field defects) or an afferent pupillary defect.

  • Consider spinal cord imaging in patients with neurologic symptoms suggestive of spinal cord involvement, which can be seen in either NMO or MOG-IgG disease.

Prognosis for Optic Neuritis

Prognosis depends on the underlying condition. Most episodes resolve spontaneously, with return of vision in 2 to 3 months. Most patients with a typical history of optic neuritis and no underlying systemic disease, such as a connective tissue disease, recover vision, but > 25% have a recurrence in the same eye or in the other eye (1 Prognosis reference Optic neuritis is inflammation of the optic nerve. Symptoms are usually unilateral, with eye pain and partial or complete vision loss. Diagnosis is primarily clinical. Treatment is directed... read more ). MRI is used to determine future risk of demyelinating disease.

Prognosis reference

Treatment of Optic Neuritis

  • Corticosteroids

Corticosteroids are an option, especially if multiple sclerosis or neuromyelitis optica are suspected. Treatment with methylprednisolone (500 mg to 1000 mg intravenously once a day) for 3 days followed by prednisone (1 mg/kg orally once a day) for 11 days may speed recovery, but ultimate vision results are no different from those with observation alone. Intravenous corticosteroids have been reported to delay onset of multiple sclerosis for at least 2 years. Treatment with oral prednisone alone does not improve vision outcome and may increase the rate of recurrent episodes. Low-vision aids (eg, magnifiers, large-print devices, talking watches) may be helpful. Other treatments, such as those used to treat multiple sclerosis, can be given if multiple sclerosis is suspected.

Key Points

  • Optic neuritis is most common among adults 20 to 40 years.

  • The most common causes are demyelinating diseases, particularly multiple sclerosis, neuromyelitis optica (NMO), and myelin oligodendrocyte glycoprotein autoantibody (MOG-IgG) disease, but infections, tumors, drugs, and toxins are other possible causes.

  • Findings include mild pain with eye movement, visual disturbances (particularly disproportionate loss of color vision), and afferent pupillary defect.

  • Consider gadolinium-enhanced MRI.

  • Corticosteroids and other treatments can be given, particularly if multiple sclerosis is suspected.

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