People may have symptoms, such as fever, weakness, and paleness, because they have too few normal blood cells.
Blood tests and a bone marrow evaluation are usually done.
Chemotherapy is given and is often effective.
(See also Overview of Leukemia Overview of Leukemia Leukemias are cancers of white blood cells or of cells that develop into white blood cells. White blood cells develop from stem cells in the bone marrow. Sometimes the development goes awry... read more )
Acute lymphoblastic leukemia (ALL) occurs in people of all ages but is the most common cancer in children, accounting for 75% of all leukemias Overview of Leukemia Leukemias are cancers of white blood cells or of cells that develop into white blood cells. White blood cells develop from stem cells in the bone marrow. Sometimes the development goes awry... read more in children younger than 15 years. ALL most often affects young children between the ages of 2 and 5 years. Among adults, it is somewhat more common in people older than 45.
In ALL, very immature leukemia cells accumulate in the bone marrow, destroying and replacing cells that produce normal blood cells, including one or more of the following:
Red blood cells Red Blood Cells The main components of blood include Plasma Red blood cells White blood cells Platelets read more , which carry oxygen in the bloodstream
White blood cells White Blood Cells The main components of blood include Plasma Red blood cells White blood cells Platelets read more , which help defend the body against infection
Platelets Platelets The main components of blood include Plasma Red blood cells White blood cells Platelets read more , small cell-like particles that help in the clotting process
The cancerous white blood cells do not function like normal white blood cells so they cannot help the body fight off infections.
The leukemia cells also are carried in the bloodstream to the liver, spleen, lymph nodes, brain, and testes, where they may continue to grow and divide. However, ALL cells can accumulate anywhere in the body. They can spread to the layers of tissue covering the brain and spinal cord (leukemic meningitis) and cause anemia, liver failure, kidney failure, and other organ damage.
Symptoms of ALL
Early symptoms of ALL result from the inability of the bone marrow to produce enough normal blood cells.
Fever and excessive sweating may indicate infection, which may result from too few normal white blood cells.
Weakness, fatigue, and paleness may result from too few red blood cells (anemia Overview of Anemia Anemia is a condition in which the number of red blood cells is low. Red blood cells contain hemoglobin, a protein that enables them to carry oxygen from the lungs and deliver it to all parts... read more ). Some people may have trouble breathing, a rapid heart rate, or chest pain.
Easy bruising and bleeding, sometimes in the form of nosebleeds or bleeding gums may result from too few platelets (thrombocytopenia Overview of Thrombocytopenia Thrombocytopenia is a low number of platelets (thrombocytes) in the blood, which increases the risk of bleeding. Thrombocytopenia occurs when the bone marrow makes too few platelets or when... read more ). In some cases, people may bleed into their brain or abdomen.
Other symptoms occur when leukemic cells invade other organs.
Leukemia cells in the brain may cause headaches, vomiting, stroke, and disturbances of vision, equilibrium, hearing, and facial muscles.
Leukemia cells in the bone marrow may cause bone and joint pain.
A sense of fullness in the abdomen and sometimes pain can result when leukemia cells cause enlargement of the liver and spleen.
Did You Know...
Diagnosis of ALL
Bone marrow examination
Blood tests, such as a complete blood count Complete blood count Doctors select tests to help diagnose blood disorders based on the person's symptoms and the results of the physical examination. Sometimes a blood disorder causes no symptoms but is discovered... read more , can provide the first evidence of ALL. The total number of white blood cells may be decreased, normal, or increased, but the number of red blood cells and the number of platelets are almost always decreased. In addition, very immature white blood cells (blasts) are present in the blood.
A bone marrow examination Bone Marrow Examination Red blood cells, most white blood cells, and platelets are produced in the bone marrow, the soft fatty tissue inside bone cavities. Sometimes a sample of bone marrow must be examined to determine... read more is almost always done to confirm the diagnosis and to distinguish ALL from other types of leukemia. Blasts are tested for chromosome abnormalities, which helps doctors determine the exact type of the leukemia and what drugs to use to treat it.
Blood and urine tests are done to detect other abnormalities, including whether leukemia cells have affected other organs.
Imaging tests may also be needed. Computed tomography (CT) or magnetic resonance imaging (MRI) is done if the person has symptoms that suggest leukemia cells in the brain. CT of the chest may be done to check for leukemia cells in the area around the lungs. CT, MRI, or ultrasonography of the abdomen may be done when internal organs are enlarged. An echocardiogram (ultrasound of the heart) may be done before starting chemotherapy because chemotherapy sometimes affects the heart.
Treatment of ALL
Treatment consists of
Other drugs, such as immunotherapy and/or targeted therapy
Rarely, stem cell transplantation or radiation therapy
Chemotherapy for leukemia
Chemotherapy is highly effective and is administered in phases:
Treatment of the brain
Consolidation and intensification
Induction chemotherapy is the initial phase of treatment. The goal of induction chemotherapy is to achieve remission by destroying leukemia cells so that normal cells can once again grow in the bone marrow. People may need to stay in the hospital for days or weeks, depending on how quickly the bone marrow recovers.
One of several combinations of drugs is used, and doses are repeated for several days or weeks. The specific combination depends on results of the diagnostic tests. One combination consists of prednisone (a corticosteroid) taken by mouth and weekly doses of vincristine (a chemotherapy drug) given with an anthracycline drug (usually daunorubicin), asparaginase, and sometimes cyclophosphamide, given intravenously. Immunotherapy Immunotherapy for Cancer Immunotherapy is used to stimulate the body's immune system against cancer. These treatments target specific genetic characteristics of the tumor cells. The genetic characteristics of tumors... read more (a treatment that uses a person's own immune system to kill cancer cells) and targeted therapy (drugs that are directed at abnormal genes or proteins in cancer cells) can be used in some patients with ALL.
Treatment of the brain usually begins during induction and may continue during all phases of treatment. Because ALL is likely to spread to the brain, treatment concentrates on treating leukemia that has spread to the brain or on preventing the spread of leukemia cells to the brain. For treatment of leukemia cells in the layers of tissue covering the brain and spinal cord (the meninges), methotrexate, cytarabine, corticosteroids, or a combination are usually injected directly into the cerebrospinal fluid, or high doses of these drugs may be given by vein (intravenously). This chemotherapy may be given in combination with radiation therapy to the brain.
The consolidation and intensification phase continues to treat bone marrow disease. Additional chemotherapy drugs, or the same drugs as were used during the induction phase, may be used a few times over a period of several weeks. For some people who are at high risk of relapse because of particular chromosomal changes found in their leukemia cells, stem cell transplantation Stem Cell Transplantation Stem cell transplantation is the removal of stem cells (undifferentiated cells) from a healthy person and their injection into someone who has a serious blood disorder. (See also Overview of... read more is done once remission occurs.
Further maintenance chemotherapy, which usually consists of fewer drugs, sometimes at lower doses, usually continues for 2 to 3 years.
Older people with ALL may not be able to tolerate the intensive regimen used for younger people. In these people, gentler induction regimens alone (without subsequent consolidation, intensification, or maintenance) is an option. Sometimes, immunotherapy or a gentler form of stem cell transplantation may be an option in some older people.
During all the above phases, blood and platelet transfusions may be necessary to treat anemia and to prevent bleeding, and antimicrobials may be needed to treat infections. Intravenous fluids and therapy with either allopurinol or rasburicase may also be used to help rid the body of harmful substances, such as uric acid, that are released when leukemia cells are destroyed.
Leukemia cells may begin to appear again (a condition termed relapse), often in the blood, bone marrow, brain, or testes. Early reappearance in the bone marrow is particularly serious. Chemotherapy is given again, and although many people respond to this repeat treatment, the disease has a strong tendency to come back again, especially in infants and in adults. When leukemia cells reappear in the brain, chemotherapy drugs are injected into the cerebrospinal fluid 1 or 2 times a week. When leukemia cells reappear in the testes, radiation therapy to the testes is given along with chemotherapy.
For people who have relapsed, high doses of chemotherapy drugs along with allogeneic stem cell transplantation Stem Cell Transplantation Stem cell transplantation is the removal of stem cells (undifferentiated cells) from a healthy person and their injection into someone who has a serious blood disorder. (See also Overview of... read more ("allogeneic" means the stem cells are from another person) offers the best chance of cure. But transplantation can be done only if stem cells can be obtained from a person who has a compatible tissue type (human leukocyte antigen Components of the Immune System The immune system is designed to defend the body against foreign or dangerous invaders. Such invaders include Microorganisms (commonly called germs, such as bacteria, viruses, and fungi) Parasites... read more [HLA]–matched). The donor is usually a sibling, but cells from matched, unrelated donors (or occasionally partially matched cells from family members or unrelated donors, as well as umbilical stem cells) are sometimes used. Stem cell transplantation is rarely used for people older than 65 because it is much less likely to be successful and side effects are much more likely to be fatal.
Therapies using monoclonal antibodies (proteins that attach specifically to the leukemia cells, tagging them for destruction) are also used in some people with relapsed ALL. In some people with relapsed ALL, chimeric antigen receptor T-cell therapy Combination Cancer Therapy Cancer drugs are most effective when given in combination. The rationale for combination therapy is to use drugs that work by different mechanisms, thereby decreasing the likelihood that resistant... read more (CAR-T) can be used. This therapy involves modifying a type of lymphocyte (T lymphocytes, also called T cells) from the person who has leukemia so that the new T cells will recognize and attack leukemia cells.
After relapse, additional treatment for people who are unable to undergo stem cell transplantation is often poorly tolerated and ineffective, frequently causing people to feel much sicker. However, remissions can occur. End-of-life care Introduction to Death and Dying Death is an intrinsic part of life, and talking about the likely outcomes of illness, including death and dying, is an important part of health care. Doctors and patients vary in the language... read more should be considered for people who do not respond to treatment.
Prognosis for ALL
Before treatment was available, most people who had ALL died within months of the diagnosis. Now, nearly 80% of children and 30 to 40% of adults with ALL are cured. For most people, the first course of chemotherapy brings the disease under control (complete remission). Children between the ages of 3 and 9 have the best prognosis. Infants and older adults fare least well. The white blood cell count at the time of diagnosis, whether the leukemia has spread to the brain, and the chromosome abnormalities in the leukemia cells also influence outcome.
The following English-language resource may be useful. Please note that the MANUAL is not responsible for the content of this resource.
Leukemia & Lymphoma Society: Acute Lymphoblastic Leukemia: General information on many aspects of acute lymphoblastic leukemia, including diagnosis, treatment options, and quality of life and monitoring