Лікування гострих побічних ефектів нейролептиків

Лікування гострих побічних ефектів нейролептиків

Symptoms

Treatment

Comments

Acute dystonic reactions (eg, oculogyric crisis, torticollis)

Benztropine IV or IM

Diphenhydramine IV or IM

Benztropine orally may prevent dystonia when given with an antipsychotic.

Laryngeal dystonia

Lorazepam IV

Intubation may be needed.

Akinesia, severe parkinsonian tremors, bradykinesia

Benztropine orally

Diphenhydramine orally

In patients with akinesia, the antipsychotic may have to be stopped, and one with a lower potency used.

Akathisia (with other extrapyramidal adverse effects)

Amantadine orally

Benztropine orally

Biperiden orally

Procyclidine orally

Propranolol orally

Trihexyphenidyl orally

The causative antipsychotic should be stopped, a lower dose of that same medication may be given, or the antipsychotic can be switched to one with a lower propensity to cause extrapyramidal adverse effects.

Akathisia associated with extreme anxiety

Lorazepam orally

Clonazepam orally