Деякі фактори ризику гіперчутливості до ліків на основі HLA
Medication | Ethnicity | HLA Haplotype | Hypersensitivity Reaction |
|---|---|---|---|
Abacavir | European ancestry | HLA-B*5701 | Abacavir hypersensitivity (usually fever, rash, and GI and respiratory symptoms) |
Allopurinol | Asian ancestry, African ancestry Less often, European ancestry | HLA-B*5801 | SJS/TEN; DRESS |
Carbamazepine | European ancestry, Japanese ancestry | HLA-A*3101 | SJS/TEN |
Carbamazepine | Asian ancestry | HLA-B*1502 | SJS/TEN; DRESS |
Dapsone | Mainland Chinese ancestry | HLA-B*1301 | DRESS |
Fosphenytoin Phenytoin | Asian ancestry | HLA-B*1502 | SJS/TEN |
Lamotrigine | Asian ancestry | HLA-B*1502 | SJS/TEN |
DRESS = drug rash with eosinophilia and systemic symptoms; GI = gastrointestinal; HLA = human leukocyte antigen; SJS/TEN = Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). | |||