MSD Manual

Please confirm that you are a health care professional

Loading

Neonatal Hyperglycemia

By

Kevin C. Dysart

, MD, Perelman School of Medicine at the University of Pennsylvania

Last full review/revision Dec 2018| Content last modified Dec 2018
Click here for Patient Education

Hyperglycemia is a serum glucose concentration > 150 mg/dL (> 8.3 mmol/L). Diagnosis is with serum glucose testing. Treatment is reduction of the IV dextrose concentration or of the infusion rate, or IV insulin.

The most common cause of neonatal hyperglycemia is

  • Iatrogenic

Iatrogenic causes usually involve too-rapid IV infusions of dextrose during the first few days of life in very low-birth-weight infants (< 1.5 kg).

The other important cause is physiologic stress caused by surgery, hypoxia, respiratory distress syndrome, or sepsis; fungal sepsis poses a special risk. In premature infants, partially defective processing of proinsulin to insulin and relative insulin resistance may cause hyperglycemia. In addition, transient neonatal diabetes mellitus is a rare self-limited cause that usually occurs in small-for-gestational-age infants; corticosteroid therapy may also result in transient hyperglycemia. Hyperglycemia is less common than hypoglycemia, but it is important because it increases morbidity and mortality of the underlying causes.

Symptoms and Signs

Symptoms and signs of neonatal hyperglycemia are those of the underlying disorder.

Diagnosis

  • Serum glucose testing

Diagnosis of neonatal hyperglycemia is by serum glucose testing. Additional laboratory findings may include glycosuria and marked serum hyperosmolarity.

Treatment

  • Reduction of IV dextrose concentration, rate, or both

  • Sometimes IV insulin

Treatment of iatrogenic hyperglycemia is reduction of the IV dextrose concentration (eg, from 10% to 5%) or of the infusion rate; hyperglycemia persisting at low dextrose infusion rates (eg, 4 mg/kg/min) may indicate relative insulin deficiency or insulin resistance.

Treatment of other causes is fast-acting insulin. One approach is to add fast-acting insulin to an IV infusion of 10% dextrose at a uniform rate of 0.01 to 0.1 unit/kg/h, then titrate the rate until the glucose level is normalized. Another approach is to add insulin to a separate IV of 10% D/W given simultaneously with the maintenance IV infusion so that the insulin can be adjusted without changing the total infusion rate. Responses to insulin are unpredictable, and it is extremely important to monitor serum glucose levels and to titrate the insulin infusion rate carefully.

In transient neonatal diabetes mellitus, glucose levels and hydration should be carefully maintained until hyperglycemia resolves spontaneously, usually within a few weeks.

Any fluid or electrolytes lost through osmotic diuresis should be replaced.

Click here for Patient Education
NOTE: This is the Professional Version. CONSUMERS: Click here for the Consumer Version
Professionals also read

Also of Interest

Videos

View All
Prenatal Heart Circulation
Video
Prenatal Heart Circulation
The heart and circulatory system of a fetus begin to form soon after conception. By the end...
3D Models
View All
Cystic Fibrosis: Defective Chloride Transport
3D Model
Cystic Fibrosis: Defective Chloride Transport

SOCIAL MEDIA

iOS Android
iOS Android
iOS Android
TOP