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Overview of Spondyloarthritis

By

Apostolos Kontzias

, MD, Stony Brook University School of Medicine

Medically Reviewed May 2020 | Modified Sep 2022
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Spondyloarthritis (also called spondyloarthropathy or spondyloarthritides) is a term used to describe a group of connective tissue diseases that cause prominent joint inflammation. These diseases affect the joints and spine and share certain characteristics. For example, they may cause back pain, inflammation of the eye (uveitis Uveitis Uveitis is inflammation anywhere in the pigmented inside lining of the eye, known as the uvea or uveal tract. The uveal tract may become inflamed because of infection, injury, a bodywide autoimmune... read more ), digestive symptoms, and rashes. Some are strongly associated with the HLA-B27 gene. Because they cause many of the same problems and share genetic characteristics, some experts think these disorders share similar causes and ways of causing symptoms.

Juvenile-onset spondyloarthritis affects the lower extremities, often affects joints on opposite sides of the body to different degrees, and begins most commonly in boys aged 7 to 16.

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