Uncontrolled hypertension

1

Abnormal kidney function

1

Abnormal liver function

1

Prior stroke

1

Prior bleeding

1

1

Older age (> 65 years)

1

Drug use (defined as concomitant use of a nonsteroidal anti-inflammatory drug [NSAID] or an antiplatelet drug)

1

Alcohol use (defined as > 8 alcohol units per week)

1